1198091-36-9Relevant academic research and scientific papers
Negishi cross-coupling reaction as a route to isocombretastatins
Malysheva, Yulia B.,Buchvalova, Svetlana Y.,Svirshchevskaya, Elena V.,Fokin, Valery V.,Fedorov, Alexey Y.
supporting information, p. 1772 - 1776 (2013/09/12)
A series of isocombretastatins A has been synthesized by a new method based on the Negishi cross-coupling reaction in 19-84% yields. Five of the synthesized compounds exhibit high cytotoxic activity in nanomolar concentrations (IC50 = 1-100 n) towards Jurkat, K562, Colo357, and A549 cell lines. Georg Thieme Verlag Stuttgart · New York.
Expeditious synthesis of 1,1-diarylethylenes related to isocombretastatin A-4 (isoCA-4) via palladium-catalyzed arylation of N-tosylhydrazones with aryl triflates
Tréguier, Bret,Hamze, Abdallah,Provot, Olivier,Brion, Jean-Daniel,Alami, Mouad
experimental part, p. 6549 - 6552 (2011/02/23)
A quick and efficient entry to 1,1-diarylethylenes via the reaction of polyoxygenated aryl N-tosylhydra-zones with aryl triflates is described. The reaction employs the catalytic system Pd(OAc)2/XPhos, tBuOLi as the base and dioxane as the solv
