1198093-76-3Relevant academic research and scientific papers
Synthesis and biological activity of new functionalized epothilones for prodrug design and tumor targeting
Dietrich, Silvia Anthoine,Riediker, Linda,Gertsch, Juerg,Altmann, Karl-Heinz
, p. 136 - 139 (2011/07/31)
Epothilones are potent antiproliferative agents, which have served as successful lead structures for anticancer drug discovery. However, their therapeutic efficacy would benefit greatly from an increase in their selectivity for tumor cells, which may be a
Epothilone analogues with benzimidazole and quinoline side chains: Chemical synthesis, antiproliferative activity, and interactions with tubulin
Dietrich, Silvia Anthoine,Lindauer, Renate,Stierlin, Claire,Gertsch, Juerg,Matesanz, Ruth,Notararigo, Sara,Diaz, Jose Fernando,Altmann, Karl-Heinz
experimental part, p. 10144 - 10157 (2010/04/30)
A series of epothilone B and D analogues bearing isomeric quinoline or functionalized benzimidazole side chains has been prepared by chemical synthesis in a highly convergent manner. All analogues have been found to interact with the tubulin/microtubule s
