1198115-49-9

Basic information

• Product Name: C₁₂H₁₁ClF₂N₄O
• CAS NO: 1198115-49-9
• Molecular Weight: 300.695
• Mol File: 1198115-49-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₁ClF₂N₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₁ClF₂N₄O(1198115-49-9)
• EPA Substance Registry System: C₁₂H₁₁ClF₂N₄O(1198115-49-9)

Safety Data

• Hazardous Substances Data: 1198115-49-9(Hazardous Substances Data)

Upstream product

• 39906-04-2 5-amino-4,6-dichloro-2-methylpyrimidine 
• 22236-10-8 4-difluoromethoxyaniline 

Downstream Products

• 1198108-95-0 dicyclopropylmethyl-[9-(4-difluoromethoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine 
• 1198109-56-6 6-chloro-9-(4-difluoromethoxyphenyl)-2,8-dimethyl-9H-purine 

Relevant articles and documents

Discovery of potent, metabolically stable purine CRF-1 antagonists with differentiated binding kinetic profiles

Optimisation of the potency of a bicyclic CRF antagonist whilst retaining metabolic stability is described. A core change and incorporation of metabolically stable lipophilic groups resulted in a further potency gain without increasing metabolic liability