Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1198160-27-8

Post Buying Request

1198160-27-8 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1198160-27-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1198160-27-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,8,1,6 and 0 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1198160-27:
(9*1)+(8*1)+(7*9)+(6*8)+(5*1)+(4*6)+(3*0)+(2*2)+(1*7)=168
168 % 10 = 8
So 1198160-27-8 is a valid CAS Registry Number.

1198160-27-8Downstream Products

1198160-27-8Relevant articles and documents

3-oxoisoindoline-1-carboxamides: Potent, state-dependent blockers of voltage-gated sodium channel nav1.7 with efficacy in rat pain models

MacSari, Istvan,Besidski, Yevgeni,Csjernyik, Gabor,Nilsson, Linda I.,Sandberg, Lars,Yngve, Ulrika,?hlin, Kristofer,Bueters, Tjerk,Eriksson, Anders B.,Lund, Per-Eric,Venyike, Elisabet,Oerther, Sandra,Hygge Blakeman, Karin,Luo, Lei,Arvidsson, Per I.

, p. 6866 - 6880 (2012/09/25)

The voltage-gated sodium channel NaV1.7 is believed to be a critical mediator of pain sensation based on clinical genetic studies and pharmacological results. Clinical utility of nonselective sodium channel blockers is limited due to serious adverse drug effects. Here, we present the optimization, structure-activity relationships, and in vitro and in vivo characterization of a novel series of NaV1.7 inhibitors based on the oxoisoindoline core. Extensive studies with focus on optimization of Na V1.7 potency, selectivity over NaV1.5, and metabolic stability properties produced several interesting oxoisoindoline carboxamides (16A, 26B, 28, 51, 60, and 62) that were further characterized. The oxoisoindoline carboxamides interacted with the local anesthetics binding site. In spite of this, several compounds showed functional selectivity versus Na V1.5 of more than 100-fold. This appeared to be a combination of subtype and state-dependent selectivity. Compound 28 showed concentration- dependent inhibition of nerve injury-induced ectopic in an ex vivo DRG preparation from SNL rats. Compounds 16A and 26B demonstrated concentration-dependent efficacy in preclinical behavioral pain models. The oxoisoindoline carboxamides series described here may be valuable for further investigations for pain therapeutics.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1198160-27-8