1198286-46-2 Usage
Uses
Used in Pharmaceutical Industry:
Tert-Butyl 4-pentanoylpiperidin-1-carboxylate is used as a building block for the synthesis of various pharmaceuticals and fine chemicals. Its versatile chemical structure allows it to be incorporated into a wide range of drug molecules, contributing to the development of new therapeutic agents.
Used in Research Industry:
In the research industry, Tert-Butyl 4-pentanoylpiperidin-1-carboxylate is used as an intermediate in the preparation of bioactive compounds. Its unique properties make it a valuable component in the synthesis of drugs and other bioactive molecules, facilitating the discovery and development of novel therapeutic agents.
Used in Drug Synthesis:
Tert-Butyl 4-pentanoylpiperidin-1-carboxylate is used as a key intermediate in the synthesis of drugs and other bioactive molecules. Its presence in the synthesis process allows for the creation of a diverse array of compounds with potential therapeutic applications, expanding the scope of available treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1198286-46-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,8,2,8 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1198286-46:
(9*1)+(8*1)+(7*9)+(6*8)+(5*2)+(4*8)+(3*6)+(2*4)+(1*6)=202
202 % 10 = 2
So 1198286-46-2 is a valid CAS Registry Number.
1198286-46-2Relevant academic research and scientific papers
Ching, Kuan-Chieh,Kam, Yiu-Wing,Merits, Andres,Ng, Lisa F. P.,Chai, Christina L. L.
, p. 9196 - 9213 (2015)
Chikungunya virus (CHIKV) is a re-emerging vector-borne alphavirus and is transmitted to humans by Aedes mosquitoes. Despite the re-emergence of CHIKV as an epidemic threat, there is no approved effective antiviral treatment currently available for CHIKV. Herein, we report the synthesis and structure-activity relationship studies of a class of thieno[3,2-b]pyrroles and the discovery of a trisubstituted thieno[3,2-b]pyrrole 5-carboxamide 15c that exhibits potent inhibitory activity against in vitro CHIKV infection. Compound 15c displayed low micromolar activity (EC50 value of ca. 2 μM) and limited cytotoxic liability (CC50 > 100 μM) therefore furnishing a selectivity index of greater than 32. Notably, 15c not only controlled viral RNA production, but efficiently inhibited the expression of CHIKV nsP1, nsP3, capsid, and E2 proteins at a concentration as low as 2.5 μM. More importantly, 15c also demonstrated broad spectrum antiviral activity against other clinically important alphaviruses such as O'nyong-nyong virus and Sindbis virus.
