1198340-45-2Relevant academic research and scientific papers
A General Copper-Catalyzed Synthesis of Ynamides from 1,2-Dichloroenamides
Mansfield, Steven J.,Smith, Russell C.,Yong, Jonathan R. J.,Garry, Olivia L.,Anderson, Edward A.
, p. 2918 - 2922 (2019)
Ynamides are accessed via copper-catalyzed coupling of Grignard or organozinc nucleophiles with chloroynamides, formed in situ from 1,2-dichloroenamides. The reaction exhibits a broad substrate scope, is readily scaled, and overcomes typical limitations in ynamide synthesis such as the use of ureas, carbamates, and bulky or aromatic amide derivatives. This modular approach contrasts with previous routes by installing both the N- and C-substituents of the ynamide as nucleophilic components.
Modular construction of 2-substituted benzo[b]furans from 1,2-Dichlorovinyl ethers
Geary, Laina M.,Hultin, Philip G.
supporting information; experimental part, p. 5478 - 5481 (2010/02/27)
"Chemical Equation Presented" (E)-1,2-Dichlorovinyl ethers and amides are easily accessible from trichloroethylene via nucleophilic addition across in situ synthesized dlchloroacetylene. A one-pot, sequential Suzukl-Miyaura coupling/intramolecular direct
