1198401-43-2Relevant academic research and scientific papers
Domino C–H Activation Reactions through Proximity Effects
Lotz, Florian,Kahle, Klaus,Kangani, Mehrnoush,Senthilkumar, Soundararasu,Tietze, Lutz F.
, p. 5562 - 5569 (2018)
Proximity effects permit C–H activation reactions without directing groups. Here competitive reactions of selected substrates were investigated which allow a domino-carbopalladation/Mizoroki–Heck reaction and a domino-carbopalladation/C–H activation reaction. In the Pd-catalyzed transformation of the enantio- and diastereopure alkyne 8a the tetra-substituted alkenes 10 and 11 were formed almost exclusively through a domino carbopalladation/Mizoroki–Heck reaction. In contrast, the diastereomer 8c only led to the acenaphthylenes 12c and 13c through a domino carbopalladation/C–H activation reaction. Moreover, in the reaction of 20, 24 and 27 containing a naphthyl moiety only the tetra-substituted alkenes 23, 25/26 and 28/29, respectively were obtained, whereas in the reaction of 34, containing a phenanthrene moiety, compound 37 was the only product, formed via a C–H activation reaction.
Synthesis of chiroptical molecular switches by Pd-catalyzed domino reactions
Tietze, Lutz F.,Duefert, Alexander,Lotz, Florian,Soelter, Lars,Oum, Kawon,Lenzer, Thomas,Beck, Tobias,Herbst-Irmer, Regine
supporting information; scheme or table, p. 17879 - 17884 (2010/03/30)
New photochromic switches based on helical alkenes can quickly and efficiently be accessed by Pd-catalyzed domino reactions using a modular approach; this allows a wide variability in product formation with the advantages of a convergent synthetic route.
