1198437-71-6

Basic information

• Product Name: 1H-Indazol-4-amine, 6-bromo-1-(phenylsulfonyl)-
• CAS NO: 1198437-71-6
• Molecular Weight: 352.211
• Mol File: 1198437-71-6.mol

Chemical Properties

• CAS DataBase Reference: 1H-Indazol-4-amine, 6-bromo-1-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazol-4-amine, 6-bromo-1-(phenylsulfonyl)-(1198437-71-6)
• EPA Substance Registry System: 1H-Indazol-4-amine, 6-bromo-1-(phenylsulfonyl)-(1198437-71-6)

Safety Data

• Hazardous Substances Data: 1198437-71-6(Hazardous Substances Data)

Usage

Explanation

The compound consists of 14 carbon atoms, 10 hydrogen atoms, 1 bromine atom, 3 nitrogen atoms, 2 oxygen atoms, and 1 sulfur atom.
2. Derivative of indazole

Explanation

The compound is based on the indazole ring system, which is a core structure in many biologically active molecules.
3. Contains a bromine atom

Explanation

The presence of bromine can influence the compound's lipophilicity, electronic properties, and potential biological activity.
4. Contains a phenylsulfonyl group
5. Potential applications in pharmaceutical and medicinal chemistry

Explanation

The compound's structure and functional groups suggest that it may exhibit biological activity, making it a candidate for further research in drug development.
6. Requires further research and testing

Explanation

To fully understand the properties and potential uses of 1H-Indazol-4-amine, 6-bromo-1-(phenylsulfonyl)-, additional studies and experiments are necessary to explore its biological activity, pharmacokinetics, and safety profile.

Upstream product

• 885518-50-3 6-bromo-1H-indazole-4-amine 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 1198437-73-8 1-((4-phenyl)sulfonyl)-6-(trimethylstannyl)-1H-indazol-4-amine 
• 1198802-85-5 2-(chloromethyl)-N-[6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide 
• 1198802-95-7 6-(chloromethyl)-N-[6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-2-pyridinecarboxamide 
• 1198802-93-5 6-(chloromethyl)-N-[6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-2-pyridinecarboxamide 
• 1198804-04-4 2-methyl-N-(6-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide 
• 1198803-99-4 N-{6-[4-(aminosulfonyl)phenyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide 

Relevant articles and documents

Indazole derivatives for use in the treatment of influenza virus infection

The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease

Optimization of lead compound 1, through extensive use of structure-based design and a focus on PI3Kδ potency, isoform selectivity, and inhaled PK properties, led to the discovery of clinical candidates 2 (GSK2269557) and 3 (GSK2292767) for the treatment of respiratory indications via inhalation. Compounds 2 and 3 are both highly selective for PI3Kδ over the closely related isoforms and are active in a disease relevant brown Norway rat acute OVA model of Th2-driven lung inflammation.

NOVEL COMPOUNDS

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF P13 KINASES

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

INDAZOLE DERIVATIVES AS PI 3 - KINASE INHIBITORS

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

NOVEL COMPOUNDS

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

4-CARBOXAMIDE INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF P13-KINASES

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity.