1198612-93-9Relevant academic research and scientific papers
Copper-catalyzed synthesis of 4-Aryl-1H-1,2,3-triazoles from 1,1-dibromoalkenes and sodium azide
Wang, Xiaokun,Kuang, Chunxiang,Yang, Qing
experimental part, p. 424 - 428 (2012/02/03)
A new methodology for the Cu-catalyzed synthesis of 1H-1,2,3-triazoles from 1,1-dibromoalkenes and sodium azide is presented. Aryl dibromoolefins were efficiently converted into the corresponding 1,2,3-triazoles. A comprehensive number of functional group
Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors
Huang, Qiang,Zheng, Maofa,Yang, Shuangshuang,Kuang, Chunxiang,Yu, Cunjing,Yang, Qing
scheme or table, p. 5680 - 5687 (2011/12/16)
Previously, we have reported the design and synthesis of 4-aryl-1H-1,2,3-triazoles as inhibitors of indoleamine 2,3-dioxygenase (IDO), a promising therapeutic target of cancer. Here, we present the structure-activity relationship and enzyme kinetic studie
Bromo-directed N-2 alkylation of NH-1,2,3-triazoles: Efficient synthesis of poly-substituted 1,2,3-triazoles
Wang, Xiao-Jun,Sidhu, Kanwar,Zhang, Li,Campbell, Scot,Haddad, Nizar,Reeves, Diana C.,Krishnamurthy, Dhileepkumar,Senanayake, Chris H.
supporting information; experimental part, p. 5490 - 5493 (2010/02/28)
"Chemical Equation Presented" Reaction of 4-bromo-NH-1,2,3- triazoles 2 with alkyl halides In the presence of K2CO3 in DMF produced the corresponding 2-substituted 4-bromo1,2,3-triazoles 5 In a regioselective process. Subsequent Suzuki cross-coupling reaction of these bromides provided an efficient synthesis of 2,4,5-trisubstituted triazoles 3. In addition, reduction of the bromotriazoles by hydrogenation furnished an efficient synthesis of 2,4-disubstituted triazoles 8.
