1198613-75-0Relevant academic research and scientific papers
Bromo-directed N-2 alkylation of NH-1,2,3-triazoles: Efficient synthesis of poly-substituted 1,2,3-triazoles
Wang, Xiao-Jun,Sidhu, Kanwar,Zhang, Li,Campbell, Scot,Haddad, Nizar,Reeves, Diana C.,Krishnamurthy, Dhileepkumar,Senanayake, Chris H.
supporting information; experimental part, p. 5490 - 5493 (2010/02/28)
"Chemical Equation Presented" Reaction of 4-bromo-NH-1,2,3- triazoles 2 with alkyl halides In the presence of K2CO3 in DMF produced the corresponding 2-substituted 4-bromo1,2,3-triazoles 5 In a regioselective process. Subsequent Suzuki cross-coupling reaction of these bromides provided an efficient synthesis of 2,4,5-trisubstituted triazoles 3. In addition, reduction of the bromotriazoles by hydrogenation furnished an efficient synthesis of 2,4-disubstituted triazoles 8.
