119866-75-0Relevant academic research and scientific papers
Protecting group for carboxyl function: Mild and facile cleavage of 2- cyanoethyl ester under non-hydrolytic conditions
Kita,Maeda,Takahashi,Fukui,Ogawa,Hatayama
, p. 147 - 150 (2007/10/02)
The use of the 2-cyanoethyl group for carboxyl-protection is described. This group was readily introduced by esterification using ethylene cyanohydrin and the deprotection was carried out under mild conditions using tetrabutylammonium fluoride in dimethylformamide-tetrahydrofuran.
3-HYDROXYPROPIONITRILE: A NEW REAGENT FOR CARBOXYL PROTECTION IN PEPTIDE SYNTHESIS
Misra, P.K.,Hashmi, S.A.N.,Haq, W.,Katti, S.B.
, p. 3569 - 3572 (2007/10/02)
3-Hydroxypropionitrile has been employed as a convenient reagent for carboxyl protection in peptide synthesis.Deblocking of this group is extremely facile and proceeds without side reactions.
PROTECTION OF THE CARBOXY GROUP IN THE FORM OF THE 2-CYANOETHYL ESTERS IN SYNTHESIS OF PEPTIDES
Kalashnikov, V. V.,Samukov, V. V.
, p. 351 - 354 (2007/10/02)
With the aim of studying the suitability of the 2-cyano group for the protection of carboxylic functions in peptide synthesis, we have obtained the 2-cyanoethyl esters of a number of amino acids and have studied their behavior under the conditions of peptide synthesis.The synthesis of the pentapeptide leucine-enkephalin has been performed with the use of 2-cyanoethyl protection for C-terminal carboxy groups throughout.The physicochemical characteristics of the compounds synthesized are given.
