119874-38-3

Basic information

• Product Name: 4-O-(4-methoxytetrahydropyran-4-yl)-2,3:5,6-di-O-isopropylidene-D-myo-inositol
• Synonyms: 4-O-(4-methoxytetrahydropyran-4-yl)-2,3:5,6-di-O-isopropylidene-D-myo-inositol
• CAS NO: 119874-38-3
• Molecular Weight: 374.431
• Mol File: 119874-38-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-O-(4-methoxytetrahydropyran-4-yl)-2,3:5,6-di-O-isopropylidene-D-myo-inositol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-O-(4-methoxytetrahydropyran-4-yl)-2,3:5,6-di-O-isopropylidene-D-myo-inositol(119874-38-3)
• EPA Substance Registry System: 4-O-(4-methoxytetrahydropyran-4-yl)-2,3:5,6-di-O-isopropylidene-D-myo-inositol(119874-38-3)

Safety Data

• Hazardous Substances Data: 119874-38-3(Hazardous Substances Data)

Upstream product

• 17327-22-9 4-methoxy-2,6-dihydropyran 
• 119943-93-0 1-O-(tert-butyldiphenylsilyl)-2,3:5,6-di-O-isopropylidene-D-myo-inositol 
• 119874-36-1 1-O-(tert-butyldiphenylsilyl)-4-O-camphanyl-2,3:5,6-di-O-isopropylidene-D-myo-inositol 
• 160636-78-2 1-O-camphanoyl-2,3:5,6-O-diisopropylidene-D-myo-inositol 
• 135950-25-3 4-methoxy-5,6-dihydro-2H-pyrane 
• 128110-25-8 (L)-1,2:4,5-di-O-isopropylidene-myo-inositol 
• 51548-88-0 (+/-)-1,2:4,5-di-O-isopropylidene-myo-inositol 
• 119874-35-0 1⁽³⁾-O-(tert-butyldiphenylsilyl)-2,3⁽¹⁾:5,6⁽⁴⁾-di-O-isopropylidene-D-myo-inositol 
• 119874-37-2 1-O-(tert-butyldiphenylsilyl)-4-O-(4-methoxytetrahydropyran-4-yl)-2,3:5,6-di-O-isopropylidene-D-myo-inositol 

Downstream Products

• 119943-95-2 1D-myo-inositol-1-(1',2'-di-O-hexadecanoyl-sn-glycer-3'-yl sodium phosphate) 
• 119874-40-7 2,3:5,6-di-O-isopropylidene-4-O-(4-methoxytetrahydropyran-4-yl)-D-myo-inositol 1-(1,2-di-O-hexadecanoyl-sn-glycer-3-yl phenyl phosphate) 
• 119874-40-7 2,3:5,6-di-O-isopropylidene-4-O-(4-methoxytetrahydropyran-4-yl)-D-myo-inositol 1-(2,3-di-O-hexadecanoyl-sn-glycer-1-yl phenyl phosphate) 

Relevant articles and documents

Inhibition of human erythrocyte membrane phosphatidylinositol 4-kinase by phospholipid analogues

Analogues of phosphatidylinositol (PtdIns, 1) have been synthesized to investigate the structural requirements for inhibition of a PtdIns 4-kinase obtained from human erythrocyte membranes. While the presence of either D-1 or D-3 stereochemistry in the inositol moiety greatly influences the degree of inhibition produced by PtdIns analogues, the stereochemistry of the glycerol moiety is of little consequence. Neither structural feature however, makes a significant contribution to binding affinity. Competitive inhibitory activity was found to be retained (or even enhanced) in substantially simpler analogues consisting of 1 or 2 hydrocarbon chains attached to a charged phosphate head group, such as in the phosphatidic acids, 24 and 26. The observation that the phosphatidylinositol 4-phosphate (PtdIns 4P) and phosphatidic acid analogues (eg, 16 or 17, and 26 respectively) inhibit PtdIns 4-kinase may suggest that such species have a regulatory role in PtdIns turnover.

Total synthesis of the four stereoisomers of dihexadecanoyl phosphatidylinositol and the substrate stereospecificity of human erythrocyte membrane phosphatidylinositol 4-kinase

A new and convenient method for the preparation of the four stereoisomers of dihexadecanoyl phosphatidylinositol has been developed. An enantiomeric pair of acid-labile, pentaprotected myo-inositol building blocks was synthesized in high yield and coupled