119887-89-7Relevant academic research and scientific papers
SUBSTITUTED PYRIDINONES
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Page/Page column 267, (2008/06/13)
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
REACTION OF ISOCYANIC ACID AND ISOCYANATES WITH DIKETENE. PREPARATION OF 2H-1,3-OXAZINES, 4-PYRONES, AND 2-PYRIDONES
Ozaki, Shoichiro,Nagase, Toshio,Kato, Takazo
, p. 2063 - 2066 (2007/10/02)
Reaction of diketene with isocyanic acid gave the expected product, 2,4-dioxo-6-methyl-3,4-dihydro-2H-1,3-oxazine (2), but with aryl isocyanates gave 3-aryl-2,4-dioxo-6-methyl-3,4-dihydro-2H-1,3-oxazines (3), 3-(arylcarbamoyl)-2,6-dimethyl-4-pyrones (4), and 3-acetyl-1-aryl-4-hydroxy-6-methyl-2-pyridones (5) depending on the reaction conditions.
