119900-89-9

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 119673-72-2 (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 88759-56-2 (S)-bromo-3-hydroxybutyric acid methyl ester 
• 119900-72-0 (S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 119673-71-1 Methyl 3S-((t-butyl)diphenylsilyloxy)-4-bromo butanoate 

Downstream Products

• 137586-41-5 (S)-4-{[6-Benzo[1,3]dioxol-4-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester 
• 137587-08-7 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]pyridin-3-ylmethoxy]-methoxy-phosphoryl}-butyric acid methyl ester 
• 135427-13-3 (S)-4-<<<4-(4-fluorophenyl)-2-(1-methylethyl)benzo<6,7>cyclohepta<1,2-b>pyridin-3-yl>ethynyl>methoxyphosphinyl>-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 137586-48-2 (S)-4-{[6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester 
• 137586-76-6 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-5,6-dihydro-benzo[h]quinolin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 135427-20-2 (S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 137593-77-2 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-({(E)-2-[5-ethyl-4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-butyric acid methyl ester 
• 137586-35-7 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-5H-indeno[1,2-b]pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 137586-98-2 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-5-methyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 137586-53-9 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[5-fluoro-4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 137635-19-9 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 137635-20-2 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 

Relevant academic research and scientific papers

Phosphorus-Containing Inhibitors of HMG-CoA Reductase. 2. Synthesis and Biological Activites of a Series of Substituted Pyrydynes Containing a Hydroxyphosphinyl Moiety

A series of 2,3,4,(5),6-substituted pyridines containing a hydroxyphosphinyl functionality have been prepared and were evaluated for their ability to inhibit the enzyme HMG-CoA reductase.Systematic substitution of both R1-R4 and X-Y

HMG-COA REDUCTASE INHIBITORS

Disclosed are novel substituted cyclohexenyl phosphinylhydroxybutyrates as 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula: STR1 and pharmaceutically acceptable salts ther