119900-72-0

Upstream product

• 116-17-6 triisopropyl phosphite 
• 119673-72-2 (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 88759-56-2 (S)-bromo-3-hydroxybutyric acid methyl ester 
• 119673-71-1 Methyl 3S-((t-butyl)diphenylsilyloxy)-4-bromo butanoate 

Downstream Products

• 137604-57-0 (S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester 
• 137587-09-8 (S)-4-[[[4-(4-Fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5H-benzo[6,7]cyclohepta [1,2-b]pyridin-3-yl]methoxy]methoxyphosphinyl]-3-hydroxybutanoic acid, methyl ester 
• 137586-49-3 (S)-4-{[6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-3-hydroxy-butyric acid methyl ester 
• 135427-14-4 (S)-4-<<<4-(4-fluorophenyl)-2-(1-methylethyl)benzo<6,7>cyclohepta<1,2-b>pyridin-3-yl>ethynyl>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester 
• 137586-42-6 (S)-4-{[6-Benzo[1,3]dioxol-4-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-3-hydroxy-butyric acid methyl ester 
• 137586-66-4 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[6-cyclopropyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 129122-73-2 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-({(E)-2-[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-butyric acid methyl ester 
• 129122-52-7 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-({(E)-2-[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-butyric acid methyl ester 
• 135427-17-7 (E),(S)-4-<<2-<4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinyl>ethenyl>methoxyphosphinyl>-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 137586-61-9 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-thiophen-2-yl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 

Relevant academic research and scientific papers

Phosphorus-containing HMG-CoA reductase inhibitors

Novel phosphorus-containing compounds which inhibit the activity of HMG-CoA reductase, including a 5-pyrimidinyl-containing moiety. Pharmaceutical compositions and methods of use for the treatment or prevention of hypercholesterolemia, atheroschlerosis, h

Phosphorus-Containing Inhibitors of HMG-CoA Reductase. 2. Synthesis and Biological Activites of a Series of Substituted Pyrydynes Containing a Hydroxyphosphinyl Moiety

A series of 2,3,4,(5),6-substituted pyridines containing a hydroxyphosphinyl functionality have been prepared and were evaluated for their ability to inhibit the enzyme HMG-CoA reductase.Systematic substitution of both R1-R4 and X-Y