119907-17-4

Upstream product

• 120019-24-1 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-phenylheptanoic acid ethyl ester 
• 59830-60-3 N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde 
• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 
• 114744-85-3 [(S)-1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester 

Downstream Products

• 1026814-91-4 {1-[(1-benzyl-3-carbamoyl-3,3-difluoro-2-hydroxy-propylcarbamoyl)-methyl]-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl}-carbamic acid benzyl ester 
• 119389-88-7 ((1S,2S)-1-Benzyl-4-tert-butoxycarbonylamino-3,3-difluoro-2-hydroxy-butyl)-carbamic acid benzyl ester 
• 119351-73-4 ((1S,2R)-1-Benzyl-4-tert-butoxycarbonylamino-3,3-difluoro-2-hydroxy-butyl)-carbamic acid benzyl ester 
• 119351-78-9 N-((S)-4-Acetylamino-1-benzyl-3,3-difluoro-2-oxo-butyl)-benzamide 
• 119860-45-6 ((S)-4-Amino-1-benzyl-3,3-difluoro-2-hydroxy-butyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis, structure - Activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase

Potent human chymase inhibitors with high enzymatic selectivity and satisfactory metabolic stability were obtained by replacing the Val-Pro (P3-P2) dipeptide portion of the previously described inhibitor 1 with a nonpeptidic pyrimidi

Difluoromethyleneketone retroamide, a versatile concept of inactivation of proteolytic enzymes

The synthesis of difluoromethyleneketone retroamides is described. Several examples of application to aspartyl or seryl proteases illustrate the versatility of this inactivation concept. Copyright

ANALOG OF PEPTIDASE SUBSTRATES

This invention relates to novel analogs of certain peptidase substrates in which the nitrogen atom of the scissile amide bond has been replaced with a difluoromethylene moiety and in which the carbonyl moiety of its adjacent amide bond has been replaced w

Novel peptidase inhibitors

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide bond of a partial retropeptide analog of the substrate has been replaced by a difluoromethylene moiety. These peptidase substrate analogs provide specific enzyme inhibitors for a variety of proteases, the inhibition of which exert valuable pharmacological activities and therefore have useful physiological consequences in a variety of disease states.

Novel peptidase inhibitors

This invention relates to activated electrophilic ketone retroamide analogs of certain peptidase substrates having the formula R1NHCHR2COCF2CHR3(NRbCOXRa)nQ These compounds are useful in inhibiting serine-, thiol-, carboxylic acid- and metallo- dependent

A CONVENIENT SYNTHESIS OF &α',&β-DIAMINO- &α,&α-DIFLUOROKETONES, NEW DIPEPTIDE ISOSTERES

A convenient and versatile synthesis of α',β-diamino-α,α-difluoroketones is described.These compounds represent a new class of true dipeptide isosteres useful for the design of serine protease inhibitors.