119963-50-7

Basic information

• Product Name: dehydrotanshinone II A
• Synonyms: dehydrotanshinone II A;1,2-Didehydrotanshinone IIA
• CAS NO: 119963-50-7
• Molecular Formula: C19H16O3
• Molecular Weight: 292.32854
• Mol File: 119963-50-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 485.2°Cat760mmHg
• Flash Point: 238.8°C
• Appearance: /
• Density: 1.235g/cm³
• Vapor Pressure: 1.44E-09mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: dehydrotanshinone II A(CAS DataBase Reference)
• NIST Chemistry Reference: dehydrotanshinone II A(119963-50-7)
• EPA Substance Registry System: dehydrotanshinone II A(119963-50-7)

Safety Data

• Hazardous Substances Data: 119963-50-7(Hazardous Substances Data)

Usage

General Description

Dehydrotanshinone II A is a natural chemical compound that is found in the root of Salvia miltiorrhiza, also known as Chinese red sage. It has been used in traditional Chinese medicine for its potential pharmacological properties. Dehydrotanshinone II A has been studied for its anti-inflammatory, antioxidant, and anticancer activities. It has been shown to possess significant cytotoxic effects against various cancer cell lines, making it a potential candidate for the development of new anticancer drugs. Additionally, it has shown promise in reducing inflammation and oxidative stress, which may have therapeutic applications in the treatment of various diseases and conditions. Overall, dehydrotanshinone II A is a bioactive compound with potential medicinal and health benefits.

InChI:InChI=1/C19H16O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h4-7,9H,8H2,1-3H3

Upstream product

• 18887-18-8 1-hydroxytanshinone IIA 
• 568-72-9 tanshinone-IIA 

Relevant articles and documents

Site-selective Csp3-H aryloxylation of natural product Tanshinone IIA and its analogues

A novel catalyst-free Csp3-H aryloxylation approach allowing for rapid installation of a wide range of aryloxyl groups regioselectively at the C-4 position of Tanshinone IIA under simple and mild conditions was developed. This unique protocol exhibited atom-/step-economy, low cost, high efficiency and robust functional-group tolerance, which will greatly facilitate to diversify the A-ring of the bioactive natural product.

Tanshinone IIA derivative with IDO/TDO doubly-selective inhibitory activity

The invention discloses tanshinone IIA derivatives, or their pharmaceutically acceptable salts, prodrugs, hydrates or solvates, a pharmaceutical composition with the tanshinone IIA derivative acting as an active ingredient, and application of the tanshinone IIA derivative in the preparation of drugs to treat tumors with IDO (indoleamine 2,3-dioxygenase) or TDO (tryptophan 2,3-dioxygenase) overexpression or evidently enhanced activity, such as glioblastoma multiforme, mesothelioma, head and neck cancer, non-small cell lung cancer, bladder cancer and breast cancer, and metabolic disorders, suchobesity, and also provides a preparation method of compounds 1 to 9. Enzymatic activity inhibition experiments prove that the compounds 1-16 can evidently inhibit IDO and TDO, and is suitable for thepreparation of drugs to treat IDO- or ITO-mediated diseases.