1199773-22-2

Basic information

• Product Name: 5-Bromo-1-cyclohexyl-1H-benzo[d]imidazole
• Synonyms: 5-Bromo-1-cyclohexyl-1H-benzo[d]imidazole
• CAS NO: 1199773-22-2
• Molecular Formula: C13H15BrN2
• Molecular Weight: 279
• Mol File: 1199773-22-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Bromo-1-cyclohexyl-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-1-cyclohexyl-1H-benzo[d]imidazole(1199773-22-2)
• EPA Substance Registry System: 5-Bromo-1-cyclohexyl-1H-benzo[d]imidazole(1199773-22-2)

Safety Data

• Hazardous Substances Data: 1199773-22-2(Hazardous Substances Data)

Usage

General Description

5-Bromo-1-cyclohexyl-1H-benzo[d]imidazole is a chemical compound belonging to the group of benzimidazoles, which are organic compounds that contain a benzene ring fused to an imidazole ring. It is recognized by its IUPAC name and often described through its molecular formula C13H14BrN. The molecular weight of this compound stands at 284.16 g/mol. It’s a brominated derivative which implies it possesses certain inherent distinguishing attributes and complex nature. Its chemical properties and reactions would typically be analyzed using techniques like nuclear magnetic resonance (NMR), mass spectrometry (MS), etc. Its applications and uses may vary depending on its purity, stability, and other factors and are largely determined within research and industrial contexts.

Upstream product

• 87815-76-7 4-bromo-N-cyclohexyl-2-nitroaniline 
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Downstream Products

• 1416553-84-8 1-cyclohexyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole 

Relevant articles and documents

Effective synthesis of benzimidazoles-imidazo[1,2-a]pyrazine conjugates: A comparative study of mono-and bis-benzimidazoles for antitumor activity

A novel series of 6-substituted-8-(1-cyclohexyl-1H-benzo[d]imidazole-6-yl)imidazo[1,2-a]pyrazine and 6-substituted-8-(1-benzyl-1H-benzo[d]imidazole-6-yl)imidazo[1,2-a]pyrazine is first time synthesized and screen in vitro biological activity for 60 human cancer cell lines representing nine different cancer types. Derivatives 10 and 36 show antitumor activity for all tested cell lines, display comparable full panel mean-graph midpoint growth inhibition (MG_MID GI50) values of 2.10 and 2.23 μM, respectively. Furthermore, these derivatives show strong binding interactions with DNA and bovine serum albumin (BSA), studied through absorption, emission, and circular dichroism techniques. These spectroscopic studies reveal that imidazo[1,2-a]pyrazine-benzimidazoles 10 and 36, intercalate with ct-DNA as a leading interaction for fundamental biologically significant effects, with monobenzimidazole show better activity than bisbenzimidazole. These experiments have confirmed that the imidazo[1,2-a]pyrazine and benzimidazole moieties are efficient pharmacophores to trigger binding to DNA. These compounds have also interacted with bovine serum albumin protein that demonstrating high values of binding constant.