1199782-67-6

Usage

Uses

Used in Pharmaceutical Research:
5-Bromo-4-chromanone is used as a key intermediate in the synthesis of pharmaceutical compounds for drug discovery. Its unique structure and reactivity make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-Bromo-4-chromanone is utilized as a versatile intermediate for the preparation of diverse chemical products. Its reactivity allows for the synthesis of various biologically active compounds, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Research:
5-Bromo-4-chromanone also finds applications in agrochemical research, where it is employed as a starting material for the synthesis of agrochemical compounds. Its potential as a building block for the development of agricultural products highlights its importance in this field.

Upstream product

• 1493-13-6 trifluorormethanesulfonic acid 
• 1016736-70-1 3-(3-bromophenoxy)propanenitrile 
• 591-20-8 3-Bromophenol 
• 18386-03-3 3-(3-bromophenoxy)propionic acid 

Relevant academic research and scientific papers

Synthesizing method for 5-bromochroman

The invention provides a synthesizing method for 5-bromochroman, and relates to the technical field of synthesis of organic chemical intermediates. The synthesizing method comprises the following steps: (1) enabling bromophenol and acrylonitrile to react

NOVEL ARYL UREA DERIVATIVE

There is a need for FAAH inhibitors capable of oral administration and having excellent efficacy, particularly agents for the prevention and treatment of pain. Disclosed are novel arylurea compounds represented by formula (I), salts or solvates thereof, and pharmaceutical compositions comprising the same as an active ingredient. The pharmaceutical composition is used primarily for FAAH inhibitors, or agents for prevention and treatment of pain.

An efficient synthesis of 4-chromanones

A two step efficient and practical synthesis of a variety of 4-chromanones is described. Phenols undergo a Michael addition to acrylonitriles in the presence of catalytic amounts of potassium carbonate and tert-butanol to generate the corresponding 3-aryloxypropanenitriles in 50-93% yields. Treatment of the resulting aryloxypropionitriles with 1.5 equiv of TfOH and 5 equiv of TFA, followed by an aqueous work up afforded 4-chromanones in moderate to excellent yields.

Efficient synthesis of chromones with alkenyl functionalities by the heck reaction

The usefulness of the Heck reaction in the field of chromones has been demonstrated. Bromochromones with the halogen atom in their rings A and B were reacted with various terminal alkenes to give hitherto unknown alkenyl-substituted chromones. Reactivity of the substrates was found to markedly depend on the position of the bromine atom. Under phosphine-free conditions using a phase-transfer catalyst additive (tetrabutylammonium bromide), shorter reaction periods and usually higher yields were obtained.