1016736-70-1

Basic information

• Product Name: 3-(3-bromophenoxy)propanenitrile
• Synonyms: 3-(3-bromophenoxy)propanenitrile
• CAS NO: 1016736-70-1
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.06992
• Mol File: 1016736-70-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3-bromophenoxy)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-bromophenoxy)propanenitrile(1016736-70-1)
• EPA Substance Registry System: 3-(3-bromophenoxy)propanenitrile(1016736-70-1)

Safety Data

• Hazardous Substances Data: 1016736-70-1(Hazardous Substances Data)

Upstream product

• 591-20-8 3-Bromophenol 
• 107-13-1 acrylonitrile 

Downstream Products

• 168759-60-2 7-bromo-4H-benzopyran-4-one 
• 1260485-23-1 5-bromochromone 
• 18442-22-3 7-Bromo-2,3-dihydro-4H-chromen-4-one 
• 1199782-67-6 5-bromo-4-chromanone 
• 1260485-26-4 (E)-7-styrylchromone 
• 18386-03-3 3-(3-bromophenoxy)propionic acid 
• 319478-14-3 5-bromochromane 

Relevant articles and documents

Acid activated montmorillonite K-10 mediated intramolecular acylation: Simple and convenient synthesis of 4-chromanones

3-Aryloxyproionic acids undergo intramolecular cyclization in the presence of AA.Mont.K-10 in toluene under reflux for 30–45 min in good to excellent yields. Phenyl ring bearing various substituents at the ortho, meta, para positions undergo this cyclization reaction. This method involves simple work up and amenable for large scale preparations. The heterogeneous acid treated catalyst can be regenerated and used for up to three cycles with minimum loss of activity.

ARYL SULFONAMIDES AS BLT1 ANTAGONISTS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are antagonists of leukotriene B4 receptor 1 (BLT1) and may be useful in the treatment, prevention and suppression of diseases mediated by the leu

An efficient synthesis of 4-chromanones

A two step efficient and practical synthesis of a variety of 4-chromanones is described. Phenols undergo a Michael addition to acrylonitriles in the presence of catalytic amounts of potassium carbonate and tert-butanol to generate the corresponding 3-aryloxypropanenitriles in 50-93% yields. Treatment of the resulting aryloxypropionitriles with 1.5 equiv of TfOH and 5 equiv of TFA, followed by an aqueous work up afforded 4-chromanones in moderate to excellent yields.