1199782-88-1

Basic information

• Product Name: 4,6-Difluoro-2,3-dihydro-1H-inden-1-aMine hydrochloride
• Synonyms: 4,6-Difluoro-2,3-dihydro-1H-inden-1-aMine hydrochloride
• CAS NO: 1199782-88-1
• Molecular Formula: C9H10ClF2N
• Molecular Weight: 205.6322064
• Mol File: 1199782-88-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4,6-Difluoro-2,3-dihydro-1H-inden-1-aMine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Difluoro-2,3-dihydro-1H-inden-1-aMine hydrochloride(1199782-88-1)
• EPA Substance Registry System: 4,6-Difluoro-2,3-dihydro-1H-inden-1-aMine hydrochloride(1199782-88-1)

Safety Data

• Hazardous Substances Data: 1199782-88-1(Hazardous Substances Data)

Upstream product

• 162548-73-4 4,6-difluoroindan-1-one 

Relevant articles and documents

Identification of N-acyl-N-indanyl-α-phenylglycinamides as selective TRPM8 antagonists designed to mitigate the risk of adverse effects

Transient receptor potential melastatin 8 (TRPM8), a temperature-sensitive ion channel responsible for detecting cold, is an attractive molecular target for the treatment of pain and other disorders. We have previously discovered a selective TRPM8 antagon

[alpha]-substituted glycineamide derivative

The present invention provides: a novel [alpha]-substituted glycineamide derivative or a pharmacologically acceptable salt thereof; a pharmaceutical composition containing the [alpha]-substituted glycineamide derivative or a pharmacologically acceptable salt thereof; and a use of the [alpha]-substituted glycineamide derivative or a pharmacologically acceptable salt thereof for medical purposes. The present invention provides a compound which has an inhibitory activity on TRPM8 and is represented by general formula (I) [wherein A1 represents a C6-10 aryl group or the like; A2 represents a C6-10 aryl group or the like; X represents CH or the like; Y represents -CR1R2- or the like; R1 and R2 independently represent a hydrogen atom or the like; R3 and R4 independently represent a halogen atom or the like; and n represents 1 or 2] or a pharmacologically acceptable salt thereof. The compound (I) according to the present invention can be used as a therapeutic or prophylactic agent for diseases or conditions associated with afferent nerve hyperexcitability or injury.