1199879-46-3Relevant academic research and scientific papers
Morpholine derivatives greatly enhance the selectivity of mammalian target of rapamycin (mTOR) inhibitors
Zask, Arie,Kaplan, Joshua,Verheijen, Jeroen C.,Richard, David J.,Curran, Kevin,Brooijmans, Natasja,Bennett, Eric M.,Toral-Barza, Lourdes,Hollander, Irwin,Ayral-Kaloustian, Semiramis,Yu, Ker
scheme or table, p. 7942 - 7945 (2010/07/07)
Dramatic improvements in mTOR-targeting selectivity were achieved by replacing morpholine in pyrazolopyrimidine inhibitors with bridged morpholines. Analogues with subnanomolarmTORIC50 values and up to 26000-fold selectivity versus PI3Kα were p
