1199942-85-2

Upstream product

• 1199942-84-1 N-trifluoroacetamido-2,4-bis-O-(2,3,4,5-tetra-O-methoxyacetyl-α-D-mannopyranosyl)-1,5-dideoxy-1,5-iminoxylitol 
• 228406-23-3 O-benzyl O-(2R)-2-hexadecanoyloxy-3-octadecanoyloxypropyl-N,N-diisopropyl phosphoramidite 

Relevant academic research and scientific papers

SYNTHETIC ANALOGUES OF PHOSPHATIDYL-MYO-INOSITOL MANNOSIDES WITH AN INHIBITORY ACTIVITY OF THE INFLAMMATORY RESPONSE

The present invention relates to novel synthetic analogues of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same and to the use thereof in the prevention or treatment of a disease associated with the overexpression of cytokines or of chemokines, in particular of TNF and/or of IL-12. The invention also relates to a pharmaceutical composition comprising at least one synthetic derivative of PIM.

Phosphatidyl myo-inositol mannosides mimics built on an acyclic or heterocyclic core: Synthesis and anti-inflammatory properties

Phosphatidyl myo-inositol mannosides (PIMs) are constituents of the mycobacterial cell wall and possess immunomodulatory activities. Certain PIM derivatives have immunoprotective activity and are of interest as anti-inflammatory agents. In order to identi