228406-23-3

Upstream product

• 108549-21-9 benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite 
• 90932-89-1 (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl octadecanoate 
• 112-76-5 Stearoyl chloride 
• 57-11-4 stearic acid 
• 282532-76-7 3-O-benzyl-2-O-hexadecanoyl-1-O-octadecanoyl-sn-glycerol 
• 4145-51-1 3-O-Benzyl-1-O-octadecanoyl-sn-glycerin 

Downstream Products

• 1196677-75-4 3,4,5,6-tetra-O-benzyl-1-O-(2,3,4,6-tetra-O-methoxyacetyl-α-D-mannopyranosyl)-2-O-((2-O-hexadecanoyl-3-O-octadecanoylpropyl)-(benzyl)phosphoryl)-D-myo-inositol 
• 1199942-85-2 N-trifluoroacetamido-2,4-bis-O-(2,3,4,6-tetra-O-methoxyacetyl-α-D-mannopyranosyl)-(3-O-((S)-2-O-hexadecanoyloxy-3-O-octadecanoyloxypropyl)(benzyl)phosphoryl)-1,5-dideoxy-1,5-iminoxylitol 
• 1346691-01-7 1-O-(2,3,4,6-tetra-O-methoxyacetyl-α-D-mannopyranosyl)-3-O-benzyl-2-O-(((S)-2-O-hexadecanoyloxy-3-O-octadecanoyloxypropyl)(benzyl)phosphoryl)-DL-glycerol 
• 1416243-89-4 N-(6-trifluoroacetamidohexanoyl)-2,4-bis-O-(2,3,4,6-tetra-O-methoxyacetyl-α-D-mannopyranosyl)-3-O-[(2R)(2-hexadecanoyloxy-3-octadecanoyloxypropyl)(benzyl)phosphoryl]-1,5-dideoxy-1,5-iminoxylitol 
• 1346691-02-8 C₆₀H₁₀₁O₁₅P 
• 1346691-07-3 2,4-bis-O-(2,3,4,6-tetra-O-methoxyacetyl-α-D-mannopyranosyl)-3-O-((S)-2-O-hexadecanoyloxy-3-O-octadecanoyloxypropyl)(benzyl)phosphoryl-1,5-anhydroxylitol 
• 1347723-70-9 2,4-bis-O-(2,3,4,6-tetra-O-methoxyacetyl-α-D-mannopyranosyl)-3-O-((S)-2-O-hexadecanoyloxy-3-O-octadecanoyloxypropyl)(benzyl)phosphoryl-1,5-anhydro-D-arabinitol 

Relevant academic research and scientific papers

Total synthesis and mass spectrometric analysis of a: Mycobacterium tuberculosis phosphatidylglycerol featuring a two-step synthesis of (R)-tuberculostearic acid

We report the total synthesis of (R)-tuberculostearic acid-containing Mycobacterium tuberculosis phosphatidylglycerol (PG). The approach features a two-step synthesis of (R)-tuberculostearic acid, involving an (S)-citronellyl bromide linchpin, and the pho

SYNTHETIC ANALOGUES OF PHOSPHATIDYL-MYO-INOSITOL MANNOSIDES WITH AN INHIBITORY ACTIVITY OF THE INFLAMMATORY RESPONSE

The present invention relates to novel synthetic analogues of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same and to the use thereof in the prevention or treatment of a disease associated with the overexpression of cytokines or of chemokines, in particular of TNF and/or of IL-12. The invention also relates to a pharmaceutical composition comprising at least one synthetic derivative of PIM.

Phosphatidyl myo-inositol mannosides mimics built on an acyclic or heterocyclic core: Synthesis and anti-inflammatory properties

Phosphatidyl myo-inositol mannosides (PIMs) are constituents of the mycobacterial cell wall and possess immunomodulatory activities. Certain PIM derivatives have immunoprotective activity and are of interest as anti-inflammatory agents. In order to identi

Phosphorylation of unnatural phosphatidylinositols with phosphatidylinositol 3-kinase

Phosphatidylinositol analogs (PI(C2)-PI(C18)) having a series of saturated fatty acid (C2-C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3- kinase). The reactivity of Pica with PI 3-kinase turned out to be comparable to that of natural PI, although PI(C18) was not phosphorylated under the same condition. The chirality of sn-2 center was not responsible for the phosphorylation reaction. (C) 2000 Elsevier Science Ltd.