1200-27-7

Basic information

• Product Name: 1-(4-Fluorophenyl)-2-methyl-2-propylamine
• Synonyms: 1-(4-Fluorophenyl)-2-methyl-2-propanamine;4-FLUOROPHENYL-2-METHYL-2-AMINOPROPANE;1-(4-FLUOROPHENYL)-2-METHYL-2-AMINOPROPANE;1-(4-FLUOROPHENYL)-2-METHYL-2-PROPYLAMINE;2-AMINO-4-FLUOROPHENYL-2-METHYLPROPANE;2-AMINO-1-(4-FLUOROPHENYL)-2-METHYLPROPANE;2-Amino-1-(4-fluorophenyl)-2-methylpropane~1,1-Dimethyl-2-(4-fluorophenyl)ethylamine~2-(4-Fluorophenyl)-tert-butylamine;1,1-Dimethyl-2-(4-fluorophenyl)ethylamine
• CAS NO: 1200-27-7
• Molecular Formula: C₁₀H₁₄FN
• Molecular Weight: 167.22
• EINECS: -0
• Product Categories: Aminomethyl's;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 1200-27-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 185-186 °C
• Boiling Point: 82-83°C 9mm
• Flash Point: >110°C
• Appearance: yellow or colorless liquid
• Density: 1.024 g/cm³
• Vapor Pressure: 0.075mmHg at 25°C
• Refractive Index: 1.495
• PKA: 9.88±0.25(Predicted)
• BRN: 2802368
• CAS DataBase Reference: 1-(4-Fluorophenyl)-2-methyl-2-propylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenyl)-2-methyl-2-propylamine(1200-27-7)
• EPA Substance Registry System: 1-(4-Fluorophenyl)-2-methyl-2-propylamine(1200-27-7)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 1200-27-7(Hazardous Substances Data)

Usage

Uses

1-(4-Fluorophenyl)-2-methyl-2-propylamine acts as a reagent in the discovery of benzooxazinones as β2-adrenoceptor agonists with 24h bronchodilatory efficacy. It is also used to synthesize oxadiazolyl ketones as novel potent DPPIV inhibitors.

InChI:InChI=1/C10H14FN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3

Upstream product

• 920289-26-5 tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-[2-(4-fluorophenyl)-1,1-dimethylethyl]-L-α-glutaminate 
• 2413-54-9 2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamine hydrochloride 
• 920289-27-6 4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester 
• 702-09-0 1-fluoro-4-(2-methylprop-1-en-1-yl)benzene 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 920289-29-8 4(S)-[(Biphenyl-4-carbonyl)-amino]-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid 

Downstream Products

• 1401436-41-6 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(1-(4-fluorophenyl)-2-methylpropan-2-yl)-6-morpholino-1,3,5-triazin-2-amine 
• 770-38-7 1-fluoro-4-isobutylbenzene 
• 1621924-49-9 (2S,4S)-4-tert-butoxycarbonylamino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester 
• 1397290-31-1 C₁₁H₁₂FN 
• 1198281-52-5 [3-(4-bromo-2-{[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamino]-methyl}-phenoxy)-phenyl]-acetic acid methyl ester 
• 958244-83-2 1-[2-(4-fluorophenyl)-1,1-dimethyl-ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]urea 
• 1079652-11-1 2-chloro-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamino]-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one 
• 1079659-15-6 3-(4-acetylpiperazin-1-yl)-5-[[1-(4-fluorophenyl)-2-methyl-propan-2-yl]amino]-8-(oxan-4-yl)-2,4,8-triazabicyclo[4.3.0]nona-1,3,5-trien-9-one 
• 920289-27-6 4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester 
• 226878-23-5 N-(α,α-Dimethyl-4-fluorophenethyl)-2-quinoxalinecarboxamide 
• 676560-66-0 (2S,5R)-5-ethynyl-1-{N-(2-(4-fluorophenyl)-1,1-dimethylethyl)glycyl}-pyrrolidine-2-carbonitrile 

Relevant articles and documents

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

POLYMORPHS OF N2-(1, 1' - BIPHENYL - 4 - YLCARBONYL) - N1- [2- (4 - FLUOROPHENYL) -1, 1 - DIMETHYLETHYL]- L - α -GLUTAMINE

Disclosed are novel polymorphic forms of N2-(1, 1'-biphenyl-4-ylcarbonyl)-N1-[2-(4- fluorophenyl)-1, 1-dimethylethyl]-L-α-glutamine, methods of preparing the polymorphic forms, compositions containing the polymorphic forms, and methods of treatment using the polymorphic forms.