1200-27-7

Usage

Uses

1. Used in Pharmaceutical Industry:
1-(4-Fluorophenyl)-2-methyl-2-propylamine is used as a reagent for the discovery of benzooxazinones as β2-adrenoceptor agonists. These agonists exhibit bronchodilatory efficacy, which can be beneficial for patients suffering from respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). The compound plays a crucial role in the development of new drugs with improved bronchodilatory properties and longer-lasting effects.
2. Used in Chemical Synthesis:
1-(4-Fluorophenyl)-2-methyl-2-propylamine is also utilized in the synthesis of oxadiazolyl ketones, which are novel and potent inhibitors of dipeptidyl peptidase IV (DPPIV). DPPIV inhibitors have gained significant attention in the pharmaceutical industry due to their potential therapeutic applications in treating type 2 diabetes and other metabolic disorders. The compound serves as a key intermediate in the synthesis of these inhibitors, contributing to the development of more effective treatments for diabetes and related conditions.

InChI:InChI=1/C10H14FN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3

Upstream product

• 702-09-0 1-fluoro-4-(2-methylprop-1-en-1-yl)benzene 
• 920289-27-6 4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester 
• 2413-54-9 2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamine hydrochloride 
• 920289-26-5 tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-[2-(4-fluorophenyl)-1,1-dimethylethyl]-L-α-glutaminate 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 920289-29-8 4(S)-[(Biphenyl-4-carbonyl)-amino]-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid 

Downstream Products

• 676560-66-0 (2S,5R)-5-ethynyl-1-{N-(2-(4-fluorophenyl)-1,1-dimethylethyl)glycyl}-pyrrolidine-2-carbonitrile 
• 226878-23-5 N-(α,α-Dimethyl-4-fluorophenethyl)-2-quinoxalinecarboxamide 
• 1079659-15-6 3-(4-acetylpiperazin-1-yl)-5-[[1-(4-fluorophenyl)-2-methyl-propan-2-yl]amino]-8-(oxan-4-yl)-2,4,8-triazabicyclo[4.3.0]nona-1,3,5-trien-9-one 
• 1079652-11-1 2-chloro-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamino]-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one 
• 1198281-52-5 [3-(4-bromo-2-{[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamino]-methyl}-phenoxy)-phenyl]-acetic acid methyl ester 
• 770-38-7 1-fluoro-4-isobutylbenzene 
• 1621924-49-9 (2S,4S)-4-tert-butoxycarbonylamino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester 
• 1397290-31-1 C₁₁H₁₂FN 
• 1401436-41-6 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(1-(4-fluorophenyl)-2-methylpropan-2-yl)-6-morpholino-1,3,5-triazin-2-amine 
• 958244-83-2 1-[2-(4-fluorophenyl)-1,1-dimethyl-ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]urea 
• 920289-27-6 4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester 

Relevant academic research and scientific papers

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

1 — (4 — Fluorophenyl) — 2 — methyl — 2 — propylamine synthetic method

The invention relates to the synthesis of organic substances, in particular to a synthetic method of 1-(4-fluorophenyl)-2-methyl-2-propylamine, comprising the following steps of: firstly, synthesizing 1,1-dimethyl parafluorobenzoic alcohol: adding magnesium powder dried at 95 DEG C by heating into an organic solution of parafluorobenzoic chloride to react, then dropping acetone to react, and then adding 5-20 percent of diluted hydrochloric acid solution, depositing a lemon-yellow organic phase and distilling off the organic solution by a rotary atmometer; secondly, synthesizing parafluoro acylamide: adding acetonitrile and acid liquor which are used as raw materials into the 1,1-dimethyl parafluorobenzoic alcohol to react, then distilling off the acetonitrile, adding a reaction liquid into water, then adding sodium hydroxide for neutralizing until the pH value reaches 6-7, separating out white solid particles, filtering and washing; and thirdly, synthesizing the 1-(4-fluorophenyl)-2-methyl-2-propylamine: adding the parafluoro acylamide and potassium hydroxide solution into a high pressure kettle, replacing with nitrogen, and then depositing a lemon-yellow oil layer to obtain a crude product. The invention has reasonable synthesis route, mild reaction, easy operation, low cost of raw materials, high product yield and high purity.

POLYMORPHS OF N2-(1, 1' - BIPHENYL - 4 - YLCARBONYL) - N1- [2- (4 - FLUOROPHENYL) -1, 1 - DIMETHYLETHYL]- L - α -GLUTAMINE

Disclosed are novel polymorphic forms of N2-(1, 1'-biphenyl-4-ylcarbonyl)-N1-[2-(4- fluorophenyl)-1, 1-dimethylethyl]-L-α-glutamine, methods of preparing the polymorphic forms, compositions containing the polymorphic forms, and methods of treatment using the polymorphic forms.