120005-03-0

Basic information

• Product Name: 2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine
• Synonyms: 2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine
• CAS NO: 120005-03-0
• Molecular Weight: 285.343
• Mol File: 120005-03-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine(120005-03-0)
• EPA Substance Registry System: 2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine(120005-03-0)

Safety Data

• Hazardous Substances Data: 120005-03-0(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 104-63-2 N-Benzylethanolamine 

Downstream Products

• 272118-16-8 3-[2-(benzyl-benzyloxycarbonyl-amino)-ethoxy]-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 166947-03-1 benzyl benzyl(2-oxoethyl)carbamate 
• 1427441-94-8 C₃₄H₄₁NO₁₄ 

Relevant articles and documents

α-Amidoaldehydes as Substrates in Rhodium-Catalyzed Intermolecular Alkyne Hydroacylation: The Synthesis of α-Amidoketones

We show that readily available α-amidoaldehydes are effective substrates for intermolecular Rh-catalyzed alkyne hydroacylation reactions. The catalyst [Rh(dppe)(C6H5F)][BArF4] provides good reactivity, and allows a broad range of aldehydes and alkynes to be used as substrates, delivering α-amidoketone products. High yields and high levels of regioselectivity are achieved. The use of α-amidoaldehydes as substrates establishes that 1,4-dicarbonyl motifs can be used as controlling groups in Rh-catalyzed hydroacylation reactions.

Preparation of Substituted Piperazinones via Tandem Reductive Amination-(N,N′-Acyl Transfer)-Cyclization

matrix presented A one-pot, tandem reductive amination-transamidation-cyclization reaction was employed to produce substituted piperazin-2-ones in good yields. Various amino acid methyl esters and transferable acyl groups were examined to establish the re