Welcome to LookChem.com Sign In|Join Free
  • or
4-[4-(4,4,5,5-Tetramethyl[1,3,2]dioxaborolan-2-yl)-2-chlorophenoxy]-2-methylpyridine is a complex organic compound with the molecular formula C18H20BNO3Cl. It features a pyridine ring with a methyl group at the 2-position and a 4-chlorophenoxy group at the 4-position. The phenoxy group is further substituted with a tetramethyl[1,3,2]dioxaborolan-2-yl group, which is a boron-containing moiety that can participate in Suzuki-Miyaura cross-coupling reactions, a type of carbon-carbon bond-forming reaction used in organic synthesis. 4-[4-(4,4,5,5-Tetramethyl[1,3,2]dioxaborolan-2-yl)-2-chlorophenoxy]-2-methylpyridine is of interest in the field of medicinal chemistry and materials science due to its potential applications in the synthesis of pharmaceuticals and other advanced materials.

1200124-83-9

Post Buying Request

1200124-83-9 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1200124-83-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1200124-83-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,0,1,2 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1200124-83:
(9*1)+(8*2)+(7*0)+(6*0)+(5*1)+(4*2)+(3*4)+(2*8)+(1*3)=69
69 % 10 = 9
So 1200124-83-9 is a valid CAS Registry Number.

1200124-83-9Relevant academic research and scientific papers

Discovery of 1,4-disubstituted 3-cyano-2-pyridones: A new class of positive allosteric modulators of the metabotropic glutamate 2 receptor

Cid, Jose María,Duvey, Guillaume,Tresadern, Gary,Nhem, Vanthea,Furnari, Rocco,Cluzeau, Philippe,Vega, Juan Antonio,De Lucas, Ana Isabel,Matesanz, Encarnación,Alonso, José Manuel,Linares, María Lourdes,Andrés, José Ignacio,Poli, Sonia M.,Lutjens, Robert,Himogai, Hassan,Rocher, Jean-Philippe,MacDonald, Gregor J.,Oehlrich, Daniel,Lavreysen, Hilde,Ahnaou, Abdelah,Drinkenburg, Wilhelmus,MacKie, Claire,Trabanco, Andrés A.

, p. 2388 - 2405 (2012/05/05)

The discovery and characterization of compound 48, a selective and in vivo active mGlu2 receptor positive allosteric modulator (PAM), are described. A key to the discovery was the rational exploration of the initial HTS hit 13 guided by an overlay model built with reported mGlu2 receptor PAM chemotypes. The initial weak in vitro activity of the hit 13 was quickly improved, although compounds still had suboptimal druglike properties. Subsequent modulation of the physicochemical properties resulted in compounds having a more balanced profile, combining good potency and in vivo pharmacokinetic properties. Final refinement by addressing cardiovascular safety liabilities led to the discovery of compound 48. Besides good potency, selectivity, and ADME properties, compound 48 displayed robust in vivo activity in a sleep-wake electroencephalogram (sw-EEG) assay consistent with mGlu2 receptor activation, in accordance with previous work from our laboratories.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 1200124-83-9