1200133-52-3Relevant academic research and scientific papers
Synthesis of functionalized pyridazin-3(2 H)-ones via nucleophilic substitution of hydrogen (SNH)
Verhelst, Tom,Verbeeck, Stefan,Ryabtsova, Oxana,Depraetere, Stefaan,Maes, Bert U. W.
, p. 272 - 275 (2011/04/22)
Reaction of 2-benzyl-5-halopyridazin-3(2H)-ones (3) with Grignard reagents followed by quenching with electrophiles unexpectedly yielded 4,5-disubstituted pyridazin-3(2H)-ones instead of 5-substituted pyridazin-3(2H)-ones. These reactions represent the fi
Synthesis of functionalized pyridazin-3(2H)-ones via bromine-magnesium exchange on bromopyridazin-3(2H)-ones
Ryabtsova, Oxana,Verhelst, Tom,Baeten, Mattijs,Vande Velde, Christophe M. L.,Maes, Bert U. W.
supporting information; experimental part, p. 9440 - 9445 (2010/03/24)
(Chemical Equation Presented) The potential of halogen-magnesium exchange reactions, followed by quenching with electrophiles, for the functionalization of the pyridazin-3(2H)-one core was investigated. 2-Benzyl-4-bromo-5-methoxy- (1), 2-benzyl-5-bromo-4-
