120033-18-3

Upstream product

• 186581-53-3 diazomethane 
• 124-38-9 carbon dioxide 
• 113202-18-9 10-(tert-butyldimethylsilyl)-phenoxazine 

Downstream Products

• 263908-49-2 10-(3,5-bis-trifluoromethylphenyl)-phenoxazine-4,6-dimethyldicarboxylate 
• 263908-59-4 10-(p-trifluoromethylphenyl)-phenoxazine-4,6-dimethyldicarboxylate 
• 263908-47-0 dimethyl 10-(m-trifluoromethylphenyl)-phenoxazin-4,6-dicarboxylate 
• 263908-52-7 10-(m-tert-butylphenyl)-phenoxazine-4,6-dimethyldicarboxylate 
• 263908-55-0 10-(p-cyanophenyl)-phenoxazine-4,6-dimethyldicarboxylate 
• 263908-51-6 10-(m-ethylphenyl)-phenoxazine-4,6-dimethyldicarboxylate 
• 263908-54-9 10-(p-nitrophenyl)-phenoxazine-4,6-dimethyldicarboxylate 
• 263908-48-1 10-(m-isopropylphenyl)-phenoxazine-4,6-dimethyldicarboxylate 
• 263908-56-1 10-(p-methoxyphenyl)-phenoxazine-4,6-dimethyldicarboxylate 
• 263908-53-8 10-(p-methylphenyl)-phenoxazine-4,6-dimethyldicarboxylate 

Relevant academic research and scientific papers

Regiospecific Lithiation of Phenoxazine Ortho to the Oxygen Atom. Synthesis of 4-Mono- and 4,6-Disubstituted Phenoxazine Derivatives

Under appropriate conditions, phenoxazine bearing a sterically demanding, bulky N-substituent (e.g., α-methylbenzyl or tert-butyldimethylsilyl) undergoes lithiation at C-4 or at C-4 and C-6 with n-butyllithium in THF solution.The lithiated species react with a variety of electrophilic reagents and upon subsequent N-deprotection provide access to 4-mono- or 4,6-disubstituted phenoxazines.This process is of particular synthetic utility (36-54percent yields) when the N-substituent is tert-butyldimethylsilyl.