120041-93-2

Upstream product

• 116762-57-3 dl-4-hydroxy-2,4-dimethyl-1-cyclohexene-1-carbaldehyde 
• 30021-64-8 ethyl 2,6-dimethyl-1,3-cyclohexadiene-1-carboxylate 
• 116762-55-1 dl-ethyl 3,4-epoxy-2,4-dimethyl-1-cyclohexene-1-carboxylate 
• 116762-58-4 dl-4-hydroxy-2,4-dimethyl-1-cyclohexene-1-carboxylic acid 
• 116762-56-2 dl-4-hydroxy-2,4-dimethyl-1-cyclohexene-1-methanol 
• 75-77-4 chloro-trimethyl-silane 

Relevant academic research and scientific papers

SYNTHETIC STUDIES ON NOGALAMYCIN CONGENERS ; TOTAL SYNTHESES OF (+)-NOGARENE, (+)-7-DEOXYNOGAROL, AND (+)-7-CON-O-METHYLNOGAROL

According to the retrosynthetic perspective, the title total syntheses were accomplished by employing the regioselective Diels-Alder reactions of the (+)-naphthoquinone (5), the CDEF-ring system of nogalamycin congeners, with various structural types of dienes (8, 16, and 26).The highly functionalized dienes (16 and 26) incorporating all the functionalities present in the A-rings of (+)-7-deoxynogarol (3) and (+)-7-con-O-methylnogarol (2), were prepared efficiently by way of the 1,4-cyclohexadiene and 2-cyclohexanone derivatives (6 and 21), respectively.Reaction mechanism of the key Diels-Alder reaction was also discussed in terms of its stereoselectivity.