1200437-75-7Relevant academic research and scientific papers
9-Arylpurines as a novel class of enterovirus inhibitors
Aguado, Leire,Thibaut, Hendrik Jan,Priego, Eva-María,Jimeno, María-Luisa,Camarasa, María-José,Neyts, Johan,Pérez-Pérez, María-Jesús
experimental part, p. 316 - 324 (2010/05/02)
Here we report on a novel class of enterovirus inhibitors that can be structurally described as 9-arylpurines. These compounds elicit activity against a variety of enteroviruses in the low μM range including Coxsackie virus A16, A21, A24, Coxsackie virus B3, and echovirus 9. Structure-activity relationship (SAR) studies indicate that a chlorine or bromine atomis required at position 6 of the purine ring for antiviral activity. The most selective compounds in this series inhibited Coxsackie virus B3 replication in a dose-dependent manner with EC50 values around 5-8 μM. Notoxicity on different cell lineswas observed at concentrations up to 250 μM. Moreover, no cross-resistance to TBZE-029 and TTP-8307 CVB3 resistant strains was detected.
