469887-23-8

Upstream product

• 87-42-3 6-chloro-7H-purine 
• 87199-15-3 [3-(hydroxymethyl)phenyl]boronic acid 
• 469887-19-2 [3-(6-chloro-5-nitro-pyrimidin-4-ylamino)-phenyl]-methanol 
• 122-51-0 orthoformic acid triethyl ester 
• 469887-21-6 N⁶-[m-(hydroxymethyl)phenyl]-4-chloro-5-aminopyrimidine 
• 1877-77-6 3-aminobenzenemethanol 

Downstream Products

• 1200437-73-5 9-[3-(hydroxymethyl)phenyl]-6-methoxypurine 
• 1200437-74-6 6-(methylamino)-9-[3-(hydroxymethyl)phenyl]purine 
• 1200437-72-4 9-[3-(hydroxymethyl)phenyl]purine 
• 1200437-75-7 9-[3-(hydroxymethyl)phenyl]hypoxanthine 
• 469887-26-1 9-[m-(hydroxymethyl)phenyl]adenine 

Relevant academic research and scientific papers

9-Arylpurines as a novel class of enterovirus inhibitors

Here we report on a novel class of enterovirus inhibitors that can be structurally described as 9-arylpurines. These compounds elicit activity against a variety of enteroviruses in the low μM range including Coxsackie virus A16, A21, A24, Coxsackie virus B3, and echovirus 9. Structure-activity relationship (SAR) studies indicate that a chlorine or bromine atomis required at position 6 of the purine ring for antiviral activity. The most selective compounds in this series inhibited Coxsackie virus B3 replication in a dose-dependent manner with EC50 values around 5-8 μM. Notoxicity on different cell lineswas observed at concentrations up to 250 μM. Moreover, no cross-resistance to TBZE-029 and TTP-8307 CVB3 resistant strains was detected.

9-[(Hydroxymethyl)phenyl]adenines: new aryladenine substrates of adenosine deaminase.

New phenyl adenine compounds 5-7 were synthesized as analogues of adenosine and studied for their adenosine deaminase (ADA) substrate activity. The 9-[(o-hydroxymethyl)phenyl]methyl]adenine 5 and 9-[(m-hydroxymethyl)phenyl]adenine 7 were deaminated by ADA