120047-51-0

Basic information

• Product Name: 3,4-Difluoro-1H-pyrrole
• Synonyms: 3,4-Difluoro-1H-pyrrole
• CAS NO: 120047-51-0
• Molecular Formula: C₄H₃F₂N
• Molecular Weight: 103.07
• Product Categories: organic building block;Porphyrins
• Mol File: 120047-51-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 45-46 °C
• Boiling Point: 144.8±20.0 °C(Predicted)
• Appearance: /
• Density: 1.353±0.06 g/cm3(Predicted)
• PKA: 14.09±0.50(Predicted)
• CAS DataBase Reference: 3,4-Difluoro-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Difluoro-1H-pyrrole(120047-51-0)
• EPA Substance Registry System: 3,4-Difluoro-1H-pyrrole(120047-51-0)

Safety Data

• Hazardous Substances Data: 120047-51-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 63, p. 5706, 1998 DOI: 10.1021/jo9805798Tetrahedron Letters, 35, p. 8605, 1994 DOI: 10.1016/S0040-4039(00)78448-6

Upstream product

• 1810-13-5 (+/-)-3,3,4,4-tetrafluoropyrrolidine hydrochloride 
• 160561-81-9 3,4-difluoro-1H-pyrrole-2-carboxylic acid 

Downstream Products

• 121399-88-0 2,3,7,8,12,13,17,18-octafluoro-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin 

Relevant articles and documents

A Straightforward Synthesis of 3,4-Difluoropyrrole

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MALT1 INHIBITORS AND USES THEREOF

The invention provides compounds of formula (I) wherein R1, R2, R3, R4 and R5 are as defined in the specification which are potent inhibitors of the enzyme MALT1 and are useful in the treatment of autoimmune disorders and diseases and as an immunooncology approach to the treatment of cancer, especially bladder cancer, colon cancer, hepatocellular cancer and small cell or non-small cell lung cancer.

First Access to 3,4-Difluoro-1H-pyrrole

N-Unsubstituted 3,4-difluoropyrrole is synthesized via a thermal cycloaddition reaction of a N-tert-butyl 2-alkoxycarbonyl aziridine and chlorotrifluoroethylene.Dealkylation of an intermediate N-tert-butylpyrrole is obtained with trifluoromethanesulfonic acid.