120060-80-2Relevant academic research and scientific papers
Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives
Maestro, Aitor,Martín-Encinas, Endika,Alonso, Concepción,Martinez de Marigorta, Edorta,Rubiales, Gloria,Vicario, Javier,Palacios, Francisco
, p. 874 - 883 (2018)
An efficient synthetic methodology for the preparation of phosphorus substituted bis-(3-indolyl)methane through a double nucleophilic addition of indole derivatives to an in situ generated α-iminophosphonate is reported. In addition, bis-(3-indolyl)methane substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell lines A549 (carcinomic human alveolar basal epithelial cell) and SKOV03 (human ovarian carcinoma).
Synthesis and plant growth regulating activity of new triazolo- and pyrazolopyrimidine derivatives of aminomethyl-, aminoalkyloxymethyl dimethylphosphine oxides and (aminomethane)phosphonic acid esters
Stanoeva, Elena,Varbanov, Sabi,Alexieva, Vera,Sergiev, Iskren,Vasileva, Vesselina,Rashkova, Marieta,Georgieva, Angelina
, p. 117 - 133 (2000)
New triazolo[4,5-d]pyrimidine and pyrazolo[3,4-d]pyrimidine derivatives of aminomethyl- and aminomethyloxymethyl dimethylphosphine oxides 8-14 as well as of esters of (aminomethane) phosphonic acid 18-20 were synthesized. The structure of the compounds prepared was confirmed by means of elemental analysis, IR, 1H- and 31P{1H}-NMR spectroscopy. Tertiary phosphine oxides 8, 9 and 12 as well as phosphonate 20 showed herbicidal and plant growth regulating activity.
Asymmetric Synthesis of α-Amino Phosphonic Acids using Stable Imino Phosphonate as a Universal Precursor
Inokuma, Tsubasa,Sakakibara, Takuya,Someno, Takatoshi,Masui, Kana,Shigenaga, Akira,Otaka, Akira,Yamada, Ken-ichi
supporting information, p. 13829 - 13832 (2019/11/05)
A practical method for synthesizing chiral α-amino phosphonic acid derivatives was developed. Readily available and stable N-o-nitrophenylsulfenyl (Nps) imino phosphonate was utilized as a substrate for a highly enantioselective Friedel–Crafts-type additi
Application of silicon-phosphorus based reagents in synthesis of aminophosphonates. Part 2: Reactions of N-(Triphenylmethyl)-aldimines with the silylated phosphorus acid esters
Boduszek,Soroka
, p. 1105 - 1111 (2007/10/03)
Reactions of silylated phosphorus acid esters with N-triphenylmethylaldimines (N-tritylaldimines) were investigated. N-Tritylmethaneimine reacts at room temperature with a mixture of P(OMe)3 and Me3SiBr forming the corresponding aminophosphonate derivatives in high yield. Other N-tritylimines are resistant toward the silylated reagents at room temperature, but undergo a similar phosphorylation reaction at elevated temperatures to form the expected aminophosphonic acids.
