120086-35-3

Basic information

• Product Name: 1-(2-THIENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE
• Synonyms: OTAVA-BB BB7017520055;AKOS BBS-00001344;1-(2-THIENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE;1-THIEN-2-YL-1,2,3,4-TETRAHYDROISOQUINOLINE;1-(THIOPHEN-2-YL)-1H,3H,4H-ISOQUINOLINE;AURORA 23246;1-Thiophen-2-yl-1,2,3,4-tetrahydro-isoquinoline
• CAS NO: 120086-35-3
• Molecular Formula: C13H13NS
• Molecular Weight: 215.31
• Mol File: 120086-35-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-THIENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-THIENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE(120086-35-3)
• EPA Substance Registry System: 1-(2-THIENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE(120086-35-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 120086-35-3(Hazardous Substances Data)

Usage

General Description

1-(2-thienyl)-1,2,3,4-tetrahydroisoquinoline is a chemical compound with a tetrahydroisoquinoline backbone and a thienyl group attached to the 1-position. It is a heterocyclic compound that exhibits a range of biological activities, including potential therapeutic effects on the central nervous system. The presence of the thienyl group may confer unique properties to the compound, making it of interest for medicinal chemistry and drug discovery. Research on 1-(2-thienyl)-1,2,3,4-tetrahydroisoquinoline and its derivatives is ongoing, with potential applications in the development of new pharmaceuticals for the treatment of neurological disorders.

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 75690-78-7 N-(2-phenylethyl)thiophene-2-carboxamide 
• 92059-63-7 1-(thiophen-2-yl)-3,4-dihydroisoquinoline 
• 64-04-0 phenethylamine 

Downstream Products

• 1229513-91-0 4-oxo-4-(1-thien-2-yl-3,4-dihydro-1H-isoquinolin-2-yl)-N-(3-(trifluoromethyl)benzyl)butyric acid amide 

Relevant articles and documents

Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists

In the course of continuing efforts to develop potent and bladder-selective muscarinic M3 receptor antagonists, quinuclidin-3-yl 1-aryl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives and related compounds were designed as conformationally restricted analogues of quinuclidin-3-yl benzhydrylcarbamate (8). Binding assays with rat muscarinic receptor subtypes revealed that the quinuclidin-3-yl 1-aryl-1,2,3,4- tetrahydroisoquinoline-2-carboxylate derivatives showed high affinities for the M3 receptor, and selectivity for the M3 receptor over the M2 receptor. Of these derivatives, (+)-(1S,3'R)-quinuclidin-3'-yl 1-phenyl-l,2,3,4-tetrahydroisoquinoline-2-carboxylate monohydrochloride (9b) exhibited almost the same inhibitory activity against bladder contraction to that of oxybutynin (1), and more than 10-fold selectivity for bladder contraction versus salivary secretion, demonstrating that 9b may be useful for the treatment of symptoms associated with overactive bladder without having side effects such as dry mouth.

Phencyclidine-like Effects of Tetrahydroisoquinolines and Related Compounds

A series of 1,2,3,4-tetrahydroisoquinolines, tetrahydrothienopyridines, and related compounds were evaluated for their ability to inhibit binding of -1--N-allylnormetazocine to phencyclidine (PCP) and ? receptors, respectively.A representative series of compounds was evaluated in behavioral assays to determine the ability of the compounds to induce PCP-like stereotyped behavior and ataxia.All of the compounds caused stereotyped behavior and ataxia, indicating their agonist actions at the PCP site.