1201-08-7

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
8-BROMO-4-HYDROXY-2-METHYLQUINOLINE is used as a building block for synthesizing other compounds, contributing to the discovery and development of new pharmaceutical agents. Its unique structure allows for the creation of diverse chemical entities with potential therapeutic applications.
Used in Materials Science:
In the field of materials science, 8-BROMO-4-HYDROXY-2-METHYLQUINOLINE is used for the development of photoactive materials and dyes. Its chemical properties, including the presence of a bromine atom and a hydroxyl group, make it suitable for creating materials with specific light-absorbing and light-emitting characteristics.
Further Exploration:
The specific properties and potential uses of 8-BROMO-4-HYDROXY-2-METHYLQUINOLINE may be further explored through research and experimentation. This could lead to the identification of additional applications in various industries, expanding its utility and impact on scientific and technological advancements.

InChI:InChI=1/C10H8BrNO/c1-6-5-9(13)7-3-2-4-8(11)10(7)12-6/h2-5H,1H3,(H,12,13)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 615-36-1 2-bromoaniline 
• 128942-73-4 C₁₂H₁₄BrNO₂ 

Relevant academic research and scientific papers

Highly Enantioselective Iron-Catalyzed cis-Dihydroxylation of Alkenes with Hydrogen Peroxide Oxidant via an FeIII-OOH Reactive Intermediate

The development of environmentally benign catalysts for highly enantioselective asymmetric cis-dihydroxylation (AD) of alkenes with broad substrate scope remains a challenge. By employing [FeII(L)(OTf)2] (L=N,N′-dimethyl-N,N′-bis(2-methyl-8-quinolyl)-cyclohexane-1,2-diamine) as a catalyst, cis-diols in up to 99.8 % ee with 85 % isolated yield have been achieved in AD of alkenes with H2O2as an oxidant and alkenes in a limiting amount. This “[FeII(L)(OTf)2]+H2O2” method is applicable to both (E)-alkenes and terminal alkenes (24 examples >80 % ee, up to 1 g scale). Mechanistic studies, including18O-labeling, UV/Vis, EPR, ESI-MS analyses, and DFT calculations lend evidence for the involvement of chiral FeIII-OOH active species in enantioselective formation of the two C?O bonds.

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.