128942-73-4

Basic information

• Product Name: (E)-3-(2-Bromo-phenylamino)-but-2-enoic acid ethyl ester
• Synonyms: (E)-3-(2-Bromo-phenylamino)-but-2-enoic acid ethyl ester
• CAS NO: 128942-73-4
• Molecular Weight: 284.153
• Mol File: 128942-73-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-3-(2-Bromo-phenylamino)-but-2-enoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2-Bromo-phenylamino)-but-2-enoic acid ethyl ester(128942-73-4)
• EPA Substance Registry System: (E)-3-(2-Bromo-phenylamino)-but-2-enoic acid ethyl ester(128942-73-4)

Safety Data

• Hazardous Substances Data: 128942-73-4(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 615-36-1 2-bromoaniline 

Downstream Products

• 1201-08-7 2-methyl-4-hydroxy-8-bromo-quinoline 
• 1201-07-6 2-methyl-4-chloro-8-bromo-quinoline 

Relevant articles and documents

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.