1201-78-1Relevant articles and documents
NEW SYNTHESES OF α-N-ALKYLACETAMIDOMETHYLATED CARBONYL COMPOUNDS
Ikeda, Kiyoshi,Terao, Yoshiyasu,Sekiya, Minoru
, p. 1156 - 1159 (2007/10/02)
Reaction of silyl enol ethers of ketones and aldehydes with 1,3,5-trialkylhexahydro-1,3,5-triazines in the presence of acetyl chloride and titanium tetrachloride afforded α-N-alkylacetamidomethylated carbonyl compounds.Thus, the reaction provides a convenient, general method for introduction of the N-alkylacetamidomethyl moiety at a position α to a carbonyl group.Keywords: N-alkylamidomethylation; 1,3,5-trialkylhexahydro-1,3,5-triazine; acetyl chloride; titanium tetrachloride; silyl enol ether