1201-91-8

Usage

Uses

Used in Optical Materials Synthesis:
N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde is used as a key intermediate in the synthesis of crosslinkable tricyanopyrroline polymeric electro-optic materials. These materials exhibit high nonlinear optical properties and are crucial for the development of advanced photonic devices and communication systems.
Used in Polymer Synthesis:
N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde is also utilized in the chemical process for synthesizing polymethacrylates, which are a class of polymers with diverse applications, including coatings, adhesives, and dental materials.
Used in Organic Synthesis:
N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde may be used to synthesize various organic compounds, such as:
1. 2,5-bis[4-(methylaminoethanol)benzylidene]cyclopentanone: N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde can be used as a precursor in the synthesis of complex organic molecules or as a building block in material science.
2. 4′-[(Tosyloxyethyl)(methyl)amino]-4-phenyl-3-buten-2-malonitrile: A tosylate precursor that can be employed in the synthesis of pharmaceuticals or other organic compounds.
3. Methanesulfonic acid 2-[(4-formyl-phenyl)-methyl-amino]-ethyl ester: This ester can be used as an intermediate in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals.

InChI:InChI=1/C10H13NO2/c1-11(6-7-12)10-4-2-9(8-13)3-5-10/h2-5,8,12H,6-7H2,1H3

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 93-90-3 N-(2-hydroxyethyl)-N-methylaminobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 1669-85-8 N-(2-chloroethyl)-N-methylaniline 
• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 50-00-0 formaldehyd 
• 19520-89-9 2-(methyl(phenyl)amino)ethyl acetate 
• 94-31-5 N-(2-chloroethyl)-N-methyl-4-aminobenzaldehyde 

Downstream Products

• 161465-10-7 N-(2-hydroxyethyl)-N-methyl-4-(1-hydroxy-2-phenylethyl)aniline 
• 1258962-94-5 trans-4-[methyl(2-hydroxyethyl)amino]-4'-methoxy-stilbene 
• 1258962-91-2 trans-4-[methyl(2-hydroxyethyl)amino]-4'-bromo-stilbene 
• 1258962-97-8 trans-4-[methyl(2-hydroxyethyl)amino]-4'-fluoro-stilbene 
• 1258962-95-6 trans-4-[methyl(2-hydroxyethyl)amino]-2'-fluoro-stilbene 
• 1258962-87-6 trans-4-[methyl(2-hydroxyethyl)amino]-2'-bromo-stilbene 
• 1258962-81-0 trans-4-[methyl(2-hydroxyethyl)amino]-2'-iodo-stilbene 
• 1258962-89-8 trans-4-[methyl(2-hydroxyethyl)amino]-3'-bromo-stilbene 
• 1258962-83-2 trans-4-[methyl(2-hydroxyethyl)amino]-3'-iodo-stilbene 
• 1258962-85-4 trans-4-[methyl(2-hydroxyethyl)amino]-4'-iodo-stilbene 
• 1258962-93-4 trans-4-[methyl(2-hydroxyethyl)amino]-2'-methoxy-stilbene 
• 910813-80-8 3-{4-[(2-hydroxy-ethyl)-methyl-amino]-phenyl}-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopro-pa[a]pentalen-4-yl)-propenone 
• 678193-55-0 4-dicyanomethylene-2-methyl-6-{4-[(2-hydroxyethyl)(methyl)amino]styryl}-4H-pyran 

Relevant academic research and scientific papers

Versatile near-infrared fluorescent probe for in vivo detection of Aβ oligomers

Amyloid-β oligomers (AβOs) enrichment in brain is highly related to Alzheimer's pathogenesis, but tracing them in the brain by imaging technique is still a great challenge due to their heterogeneity and metastability. Herein, a new near-infrared (NIR) fluorescent probe, namely, PTO-41, was designed and synthesized to specifically target AβOs. PTO-41 possesses excellent functional properties including optimal fluorescent properties (emission maxima at 680 nm upon interacting with AβOs), high affinity (Kd = 349 nM), low cell toxicity, desirable lipophilicity (log P = 2.24), and fast wash out from the brain (brain2 min/brain60 min = 5.0). Furthermore, PTO-41 exhibits a high sensitivity toward AβOs in vitro phantom imaging experiments. More importantly, PTO-41 shows great capacity to differentiate between 4-month-old APP/PS1 model mice from age-matched control mice using in vivo imaging. In summary, PTO-41 almost meets all the requirements as a versatile NIR fluorescent probe for the detection of AβOs both in vitro and in vivo.

Amphiphilic nonlinear optical bis-chromophores and their mixtures with amphotropic copolymers: Preparation of monolayers and Langmuir - Blodgett multilayers

A new type of bis-chromophores containing two successive, covalently linked, nonlinear optical (NLO) dyes has been synthesized. For their preparation, α-cyanocinnamates or dinitrophenylhydrazones have been combined with an 4′-alkoxybiphenyl-4-carboxylate

A Multiaddressable Dyad with Switchable Cyan/Magenta/Yellow Colors for Full-Color Rewritable Paper

Reversible multicolor displays on solid media created from single-molecule pigments are a long-awaited goal. Herein, a new and simple molecular dyad, which can undergo switchable cyan (C), magenta (M), and yellow (Y) color changes in both solution and the solid state upon exposure to light, water/acid, and nucleophiles, has been designed and synthesized. The stimuli used herein can be applied independent of each other, which is beneficial for color changes without mutual interference. For comparison, mixtures of the two molecular switching motifs that form the basis of the dyad were also studied. The dyad greatly outperforms the corresponding mixed system with respect to reversible color switching on the paper substrate. Its potential for full-color rewritable paper with excellent reversibility has been demonstrated. Legible multicolor prints, that is, high color contrast and resolution, good dispersion, and excellent reversibility, were achieved by using common water-jet and light-based printers. This work provides a very promising approach for the further development of full-color switchable molecules, materials, and displays.

Mitochondria two-photon fluorescence viscosity probe and preparation method thereof

The invention discloses a mitochondria two-photon fluorescence viscosity probe and a preparation method thereof. The structural formula of the mitochondria two-photon fluorescence viscosity probe is defined in the description. A target molecule has the go

Chemoselective hydrogen peroxide oxidation of primary alcohols to aldehydes by a water-soluble and reusable iron(iii) catalyst in pure water at room temperature

Hydrogen peroxide oxidation of primary alcohols to aldehydes is described, which is catalyzed by a novel, reusable and water-soluble FeCl3 complex in situ-formed with quaternary ammonium salt-functionalized 8-aminoquinoline. This reaction exhibits unique chemoselectivity and broad functional-group tolerance, and it can operate efficiently in pure water at room temperature.

The flocculated acryloyldimethyltauric molecule ligand

Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.

Four divalent metal thiocyanate coordination compounds containing a rigid functional pyridine ligand

A series of new coordination compounds Zn(SCN)2L2 (1), Co(SCN)2L2 (2), [Cd(SCN)2L2·2L]n (3) and [CdHg(SCN)4L2]n (4) have been prepared by self-as

Modifications of DCDHF single molecule fluorophores to impart water solubility

A series of dicyanomethylenedihydrofuran (DCDHF) fluorophores with different hydrophilic groups were synthesized and their photophysical properties and water solubilities were measured. Significant water solubility was achieved without compromising desirable photophysical properties, permitting applications of these fluorophores in biological systems.

LONG WAVELENGTH THIOL-REACTIVE FLUOROPHORES

Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodiaxazole nucleus, coumarin nucleus or aza coumarin nucleus.

HYDRAZONE DERIVATIVE

A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof