120106-68-5Relevant academic research and scientific papers
Potassium tert -Butoxide Promoted Synthesis of 4,5-Diaryl-2 H -1,2,3-triazoles from Tosylhydrazones and Nitriles
Qiu, Shanguang,Chen, Yuxue,Song, Xinming,Liu, Li,Liu, Xi,Wu, Luyong
, p. 86 - 90 (2020/11/02)
Intermolecular cycloaddition of tosylhydrazones with nitriles was investigated. t -BuOK was shown to be an excellent base for increasing the effectiveness of the reaction in this protocol, and homocoupling of the tosylhydrazones was significantly inhibited by using xylene as a solvent. Through this transformation, a variety of 4,5-diaryl-2 H -1,2,3-triazoles were prepared in good to excellent yields and with high purities. The process is azide-free and transition-metal-free.
THE REACTIONS OF HYDRAZONES AND RELATED COMPOUNDS WITH STRONG BASES. PART 4. 4,5-DIARYL-1,2,3-TRIAZOLES FROM AROMATIC ALDEHYDE AZINES AND FROM THE REACTION OF ARENECARBONITRILES WITH ARYLDIAZOMETHANES
Grundon, Michael F.,Khan, Ejaz A.
, p. 2917 - 2920 (2007/10/02)
Reaction of aromatic aldehyde azines in dimethyl sulphoxide at 20 deg C with potassium t-butoxide gave 4,5-diaryl-1,2,3-triazoles (4) and stilbenes.Mechanisms were studied by addition of possible intermediates and by (14)C tracer methods.The synthesis of 4,5-diaryl-1,2,3-triazoles from arenecarbonitriles, aryldiazomethanes, and potassium t-butoxide in toluene is described and the mechanism is discussed.
