56643-75-5Relevant articles and documents
A Photoregulated Racemase Mimic
Saha, Monochura,Hossain, Munshi Sahid,Bandyopadhyay, Subhajit
supporting information, p. 5220 - 5224 (2021/01/18)
The racemase enzymes convert L-amino acids to their D-isomer. The reaction proceeds through a stepwise deprotonation–reprotonation mechanism that is assisted by a pyridoxal phosphate (PLP) coenzyme. This work reports a PLP–photoswitch–imidazole triad where the racemization reaction can be controlled by light by tweaking the distance between the basic residue and the reaction centre.
Preparation and characterization of a novel poly-geminal dicationic ionic liquid (PGDIL)
Guo, Yanni,He, Deliang,Xie, Aomei,Qu, Wei,Tang, Yining,Shang, Jun,Zhu, Rilong
, (2019/10/28)
1,4-bis(3-(m-aminobenzyl)imidazole-1-yl)butane bis(hexafluorinephosphate), a novel geminal dicationic ionic liquid (GDIL) containing anilino groups has been synthesized to prepare a novel poly-geminal dicationic ionic liquid film by electro-polymerization. The morphology and structure of the PGDIL film were analyzed by SEM and FTIR, and a possible polymerization mechanism of GDIL on an Au electrode surface was determined to be 3D instantaneous nucleation. The existence of polyaniline-like units in the PGDIL chain was confirmed by FTIR, indicating that the anilino groups of GDIL were electro-polymerized on the surface of the Au electrode using the chronoamperometry method. The electrochemical performance of the PGDIL film in phenol was studied by cyclic voltammetry, and it was determined that the PGDIL film electrode promoted enhanced phenol electrocatalysis compared to the untreated Au electrode. This work extends the application range of poly ionic liquids and associates ionic liquids with conductive polymers. Where further studies on other physical and chemical properties of polymers will be necessary.
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. identification of a suitable "back-up" compound for N-tert-butyl isoquine
O'Neill, Paul M.,Shone, Alison E.,Stanford, Deborah,Nixon, Gemma,Asadollahy, Eghbaleh,Park, B. Kevin,Maggs, James L.,Roberts, Phil,Stocks, Paul A.,Biagini, Giancarlo,Bray, Patrick G.,Davies, Jill,Berry, Neil,Hall, Charlotte,Rimmer, Karen,Winstanley, Peter A.,Hindley, Stephen,Bambal, Ramesh B.,Davis, Charles B.,Bates, Martin,Gresham, Stephanie L.,Brigandi, Richard A.,Gomez-de-las-Heras, Federico M.,Gargallo, Domingo V.,Parapini, Silvia,Vivas, Livia,Lander, Hollie,Taramelli, Donatella,Ward, Stephen A.
supporting information; experimental part, p. 1828 - 1844 (2009/12/31)
On the basis of a mechanistic understanding of the toxicity of the 4-aminoquinoline amodiaquine (1b), three series of amodiaquine analogues have been prepared where the 4-aminophenol "metabolic alert" has been modified by replacement of the 4'-hydroxy gro
