1201080-23-0

Upstream product

• 126360-59-6 methyl 3-(N-acetyl)amino-4-hydroxybenzoate 
• 536-25-4 methyl 3-amino-4-hydroxybenzoate 
• 1201080-20-7 methyl 3-acetamido-4-ethoxybenzoate 

Downstream Products

• 848133-76-6 7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile 
• 848133-75-5 3-cyano-4-hydroxyl-6-acetamido-7-ethoxyquinoline 
• 1222172-50-0 methyl 5-acetamido-2-[(2-cyanovinyl)amino]-4-ethoxybenzoate 
• 1222172-49-7 methyl 5-acetamido-2-amino-4-ethoxybenzoate 
• 1201080-09-2 N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide 
• 1222172-56-6 C₁₁H₁₅N₃O₃ 
• 1222172-57-7 2-[(2-Cyanovinyl)amino]-4-ethoxy-5-acetylamido benzoylamide 
• 1222172-55-5 4-Ethoxy-5-acetylamido-2-nitro-benzoylamide 

Relevant academic research and scientific papers

A new and improved process for N -(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide

A new and improved synthetic route to N-(4-chloro-3-cyano-7-ethoxyquinolin- 6-yl)acetamide (1) is described on a kilogram scale. The key step is the basic cyclization of o-[(2-cyanovinyl)amino]benzoate (14) in tBuONa/ tBuOH system to give the 3-cyano-4-hydroxyquinoline (7). The final product 1 is obtained with 49% overall yield (seven steps) and 98.9% purity (HPLC), which makes it a cost-effective and commercially friendly process for scale-up operations.

PREPARATION METHODS OF 6-SUBSTITUTED AMINO-3-CYANOQUINOLINE COMPOUNDS AND THE INTERMEDIATES THEREOF

The present invention relates to a method for preparing 6-substituted amino-3-cyanoquinoline compounds (compound A for short) and the intermediates thereof, more particularly, to a compound of the following formula (I), the preparation method thereof, the intermediates thereof and use thereof for preparing the compound A. The compound of the formula (I) is cyclized in the presence of an alkali to give a compound of formula A, wherein W is OH; or the compound of the formula (I) is cyclized in the presence of an alkali, and then chlorinated to give a compound of the formula A, wherein W is Cl. Compared with the known methods in the literature, the method for preparing the compound A from the compound of formula (I) according to the present invention can avoid using high-temperature condition and high boiling point solvents, and is safe and environment-friendly, mild in reaction condition, easy in operation with a high yield and high product purity.