126360-59-6

Basic information

• Product Name: methyl 3-(N-acetyl)amino-4-hydroxybenzoate
• Synonyms: methyl 3-(N-acetyl)amino-4-hydroxybenzoate
• CAS NO: 126360-59-6
• Molecular Weight: 209.202
• Mol File: 126360-59-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl 3-(N-acetyl)amino-4-hydroxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(N-acetyl)amino-4-hydroxybenzoate(126360-59-6)
• EPA Substance Registry System: methyl 3-(N-acetyl)amino-4-hydroxybenzoate(126360-59-6)

Safety Data

• Hazardous Substances Data: 126360-59-6(Hazardous Substances Data)

Upstream product

• 75-36-5 acetyl chloride 
• 536-25-4 methyl 3-amino-4-hydroxybenzoate 
• 136663-21-3 methyl 2-methyl-1,3-benzoxazole-5-carboxylate 
• 7732-18-5 water 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 75-05-8 acetonitrile 
• 67-56-1 methanol 
• 91004-38-5 3-acetamido-4-hydroxybenzoic acid 
• 1571-72-8 3-amino-4-hydroxybenzoic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 1201080-09-2 N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide 
• 1201080-46-7 5-acetamido-4-ethoxy-2-nitrobenzoyl chloride 
• 1356916-92-1 3-acetamido-4-ethoxybenzoic acid 
• 1201080-29-6 5-acetamido-4-ethoxy-2-nitrobenzoic acid 
• 1201079-42-6 ethyl 3-(5-acetamido-4-ethoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate 
• 1201079-16-4 N-[5-(2-cyanoacetyl)-2-ethoxy-4-nitrophenyl]acetamide 
• 1201079-19-7 N-{5-[2-cyano-3-(N,N-dimethylamino)acryloyl]-2-ethoxy-4-nitrophenyl}acetamide 
• 91004-38-5 3-acetamido-4-hydroxybenzoic acid 
• 848133-76-6 7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile 
• 1222172-50-0 methyl 5-acetamido-2-[(2-cyanovinyl)amino]-4-ethoxybenzoate 
• 1222172-49-7 methyl 5-acetamido-2-amino-4-ethoxybenzoate 
• 1201080-23-0 methyl 5-acetamido-4-ethoxy-2-nitrobenzoate 
• 1201080-20-7 methyl 3-acetamido-4-ethoxybenzoate 

Relevant articles and documents

Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors

Fe(II)/α-ketoglutarate-dependent lysine demethylases (KDMs) are attractive drug targets for several diseases including cancer. In this study, we designed and screened ortho-substituted anilides that are expected to function as Fe(II) chelators, and identified ortho-hydroxy anilide as a novel scaffold for KDM5A inhibitors. Treatment of human lung cancer A549 cells with a prodrug form of 4-carboxy-2-hydroxy-formanilide (9c) increased trimethylated lysine 4 on histone H3 level, suggesting KDM5 inhibition in the cells.

A new and improved process for N -(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide

A new and improved synthetic route to N-(4-chloro-3-cyano-7-ethoxyquinolin- 6-yl)acetamide (1) is described on a kilogram scale. The key step is the basic cyclization of o-[(2-cyanovinyl)amino]benzoate (14) in tBuONa/ tBuOH system to give the 3-cyano-4-hydroxyquinoline (7). The final product 1 is obtained with 49% overall yield (seven steps) and 98.9% purity (HPLC), which makes it a cost-effective and commercially friendly process for scale-up operations.

Synthesis of n-(3-cyano-7-ethoxy-1,4-dihydro-4-oxoquinolin-6-yl)acetamide

New route for the preparation of N-(3-cyano-7-ethoxy-1,4-dihydro-4- oxoquinolin-6-yl)acetamide (1), a key intermediate for the synthesis of selective EGFR kinase inhibitors, was described.