120109-75-3

Basic information

• Product Name: 2-AMINO-4-CYCLOPROPYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-Amino-4-cyclopropyl-thiophene-3-carboxylic acid ethyl ester; 3-thiophenecarboxylic acid, 2-amino-4-cyclopropyl-, ethyl ester; ethyl 2-amino-4-cyclopropylthiophene-3-carboxylate
• CAS NO: 120109-75-3
• Molecular Formula: C₁₀H₁₃NO₂S
• Molecular Weight: 211.28
• Mol File: 120109-75-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 330.2°Cat760mmHg
• Flash Point: 153.5°C
• Appearance: /
• Density: 1.291g/cm³
• Vapor Pressure: 0.000169mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 2-AMINO-4-CYCLOPROPYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-CYCLOPROPYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER(120109-75-3)
• EPA Substance Registry System: 2-AMINO-4-CYCLOPROPYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER(120109-75-3)

Safety Data

• Hazardous Substances Data: 120109-75-3(Hazardous Substances Data)

Usage

Uses

Ethyl 2-amino-4-cyclopropylthiophene-3-carboxylate acts as a reagent in the preparation, SAR, pharmacokinetics and JNK inhibitory activity of substituted thiophenes starting from carboxylic acids and aminothiophenes.

InChI:InChI=1/C10H13NO2S/c1-2-13-10(12)8-7(6-3-4-6)5-14-9(8)11/h5-6H,2-4,11H2,1H3

Upstream product

• 17407-28-2 (E,Z)-ethyl 2-cyano-3-cyclopropyl-2-butenoate 
• 109-89-7 diethylamine 
• 105-56-6 ethyl 2-cyanoacetate 
• 765-43-5 Cyclopropyl methyl ketone 
• 120109-72-0 ethyl 2-cyano-3-cyclopropyl-2-butenoate 

Downstream Products

• 1292805-13-0 C₁₉H₂₁NO₄S 
• 120109-79-7 4-cyclopropyl-2-(N-acetylamino)-3-carbethoxythiophene 

Relevant articles and documents

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

The present application relates to cannabinoid receptor ligands containing compounds of formula (I) wherein A, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

SYNTHESIS AND NITRATION OF SOME 4-CYCLOPROPYL- AND 4-(p-CYCLOPROPYLPHENYL)-2-AMINOTHIOPHENES

A number of cyclopropyl-substituted crotononitriles have been synthesized by a Knoevenagel condensation. Reaction of these compounds with sulfur in the presence of a base gives substituted 4-cyclopropyl- and 4-cyclopropylphenyl-2-aminothiophenes, while nitration of some acetylaminothiophenes with acetyl nitrate in acetic anhydride at low temperature gives the corresponding nitro derivatives.