1201129-58-9

Basic information

• Product Name: C₂₈H₂₂O₄
• Synonyms: C₂₈H₂₂O₄
• CAS NO: 1201129-58-9
• Molecular Weight: 422.48
• Mol File: 1201129-58-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₂O₄(1201129-58-9)
• EPA Substance Registry System: C₂₈H₂₂O₄(1201129-58-9)

Safety Data

• Hazardous Substances Data: 1201129-58-9(Hazardous Substances Data)

Upstream product

• 19826-29-0 (E)-3,4-dihydroxystilbene 

Relevant articles and documents

Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol

Resveratrol is a well-known natural antioxidant and cancer chemopreventive agent that has attracted much nterest in the past decade. Resveratrol-directed compounds were synthesized, and their antioxidant effects gainst reactive oxygen species (ROS)-induced DNA damage, their prooxidant effects on DNA damage in he presence cupric ions, and their cytotoxic and apoptosis-inducing effects on human promyelocytic leukemia(HL-60) cells were investigated in vitro. It was found that the compounds bearing o-diphenoxyl groups exhibited remarkably higher activities in inhibiting ROS-induced DNA damage, accelerating DNA damage in the presence cupric ions, and inducing apoptosis of HL-60 cells compared with the ones bearing no such groups. The detail mechanism of the structure-activity relationship was also studied by the oxidative product analysis of resveratrol and its analogues with galvinoxyl radical or cupric ions and UV-visible spectra change in the presence cupric ions. This study reveals a good and interesting correlation between antioxidant and prooxidant activity, as well as cytotoxicity and apoptosis-inducing activity against HL-60 cells, and provides an idea for designing antioxidant-based cancer chemoprevention agents. ?2009 American Chemical Society.