1201180-97-3

Basic information

• Product Name: 5-[(2S)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile
• Synonyms: 5-[(2S)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile;(S)-3-(5-(2-aMinopropyl)-7-cyanoindolin-1-yl)propyl benzoate(2S,3S)-2,3-dihydroxysuccinate
• CAS NO: 1201180-97-3
• Molecular Formula: C22H25N3O2
• Molecular Weight: 363.4528
• Mol File: 1201180-97-3.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 567.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• PKA: 9.65±0.10(Predicted)
• CAS DataBase Reference: 5-[(2S)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(2S)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile(1201180-97-3)
• EPA Substance Registry System: 5-[(2S)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile(1201180-97-3)

Safety Data

• Hazardous Substances Data: 1201180-97-3(Hazardous Substances Data)

Upstream product

• 1338365-54-0 5-(2-aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-7-cyano-1H-indole 
• 350797-57-8 C₂₂H₂₂N₂O₃ 

Relevant articles and documents

Improved Preparation of Silodosin

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5-substituted indoline derivative or salt thereof, preparation method and application of 5-substituted indoline derivative or salt thereof, and preparation method of silodosin

The invention relates to the technical field of medicines, in particular to a 5-substituted indoline derivative or a salt thereof, a preparation method and application of the 5-substituted indoline derivative or the salt thereof, and a preparation method of silodosin. Silodosin can be prepared by taking the 5-substituted indoline derivative provided by the invention as an intermediate through first N-alkylation, bromination, cyano substitution, deprotection, second N-alkylation and hydrolysis. The reaction route is short, and the total yield of the silodosin is high. The 5-substituted indoline derivative salt provided by the invention has good stability. According to the method, phthalic anhydride or substituted phthalic anhydride and D-alanine are taken as starting materials, the 5-substituted indoline derivative can be obtained through condensation, acylating chlorination, Friedel-Crafts reaction, reduction and hydrolysis, the reaction route is short, chiral construction does not need resolution, the atom utilization rate is high, the total yield is larger than 57.5%, and the yield is high; and the raw materials are cheap and easily available, and the production cost is low.

Silodosin intermediate preparing method

The invention discloses a silodosin intermediate preparing method. The silodosin intermediate preparing method comprises the following steps of S1, subjecting 5-bromoindoline solution and triethylamine to alkylation reaction to obtain a material A; S2, su