120133-83-7Relevant academic research and scientific papers
THE SYNTHESIS OF AMINO ACIDS BY REACTION OF AN ELECTROPHILIC GLYCINE CATION EQUIVALENT WITH NEUTRAL CARBON NUCLEOPHILES
O'Donell, Martin J.,Benett, William D.
, p. 5389 - 5402 (2007/10/02)
Seven neutral carbon nucleophiles (active aromatics, allylsilanes and a silyl enol ether) were reacted with the glycine cation equivalent 12 in the presence of TiCl4 to yield α-substituted amino acid derivatives in moderate yield (1-61.5 mmolar scale).Deprotection of the Schiff base ester products led to the corresponding amino acids.
