120145-22-4

Basic information

• Product Name: 2-Chloro-6-Isopropylpyridine
• Synonyms: 2-Chloro-6-Isopropyl;2-CHLORO-6-ISOPROPYL-PYRIDINE,97%;2-Chloro-6-isopropylpyridine;2-chloro-6-(propan-2-yl)pyridine;Pyridine, 2-chloro-6-(1-Methylethyl)-
• CAS NO: 120145-22-4
• Molecular Formula: C₈H₁₀ClN
• Molecular Weight: 155.62
• Mol File: 120145-22-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 189.1±20.0 °C(Predicted)
• Appearance: /
• Density: 1.075±0.06 g/cm3(Predicted)
• Refractive Index: 1.512
• PKA: 0.91±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-6-Isopropylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-Isopropylpyridine(120145-22-4)
• EPA Substance Registry System: 2-Chloro-6-Isopropylpyridine(120145-22-4)

Safety Data

• Hazardous Substances Data: 120145-22-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-6-isopropylpyridine is a chemical compound. Its molecular formula is C8H10ClN, indicating that it contains carbon, hydrogen, chlorine, and nitrogen atoms. In terms of its structure, the compound belongs to the class of organic compounds known as pyridines and derivatives. These are compounds containing a pyridine ring, which is a six-membered aromatic heterocycle made up of one nitrogen atom and five carbon atoms. The health risks and safety hazards associated with handling 2-Chloro-6-isopropylpyridine are not fully known, with particular information gaps related to its carcinogenic potential and toxicity levels. As with any chemical, it should be handled with care, following all appropriate safety protocols and precautions.

InChI:InChI=1/C8H10ClN/c1-6(2)7-4-3-5-8(9)10-7/h3-6H,1-2H3

Upstream product

• 75-30-9 2-iodo-propane 
• 1184955-13-2 2-tert-butoxy-6-isopropylpyridine 
• 18368-63-3 6-chloro-2-picoline 

Downstream Products

• 1184955-18-7 diphenyl[6-(isopropyl)-2-pyridyl]phosphine 

Relevant articles and documents

Radical chain monoalkylation of pyridines

The monoalkylation of N-methoxypyridinium salts with alkyl radicals generated from alkenes (via hydroboration with catecholborane), alkyl iodides (via iodine atom transfer) and xanthates is reported. The reaction proceeds under neutral conditions since no acid is needed to activate the heterocycle and no external oxidant is required. A rate constant for the addition of a primary radical to N-methoxylepidinium >107 M-1 s-1 was experimentally determined. This rate constant is more than one order of magnitude larger than the one measured for the addition of primary alkyl radicals to protonated lepidine demonstrating the remarkable reactivity of methoxypyridinium salts towards radicals. The reaction has been used for the preparation of unique pyridinylated terpenoids and was extended to a three-component carbopyridinylation of electron-rich alkenes including enol esters, enol ethers and enamides.

6-Alkyl-N,N-disubstituted-2-pyridinamines as anticonvulsant agents

The anticonvulsant effect of a series of 6-alkyl-N,N-disubstituted-2-pyridinamines is described. An investigation was carried out to optimize the anticonvulsant activity and reduce behavioral side effects in this series. Three compounds (7, 8, 10; Table I) were selected from initial screening for a more complete pharmacological evaluation. While each of these compounds was a potent anticonvulsant agent with ED50 values from 5 to 10 mg/kg, the activity was accompanied by significant behavioral side effects including decreased spontaneous locomotion, ataxia, and ptosis.