120155-77-3Relevant academic research and scientific papers
Dual-reagent organocatalysis with a phosphine and electron-deficient alkene: application to the Henry reaction
Wang, Xiu,Fang, Fan,Zhao, Chen,Tian, Shi-Kai
, p. 6442 - 6444 (2008)
Triphenylphosphine in combination with methyl acrylate was found to be able to catalyze the Henry (nitroaldol) reaction of various aldehydes and α-keto esters to give the corresponding β-nitroalkanols in good to excellent yields, and a catalytic cycle involving a zwitterionic phosphine-alkene adduct was proposed for this dual-reagent organocatalysis according to the deuterium-labeling experiments with CD3NO2.
