120157-99-5Relevant academic research and scientific papers
PURINE DERIVATIVES WITH ACTIVITY TO THE ADENOSINE A2A RECEPTOR
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Page/Page column 43, (2008/06/13)
A compound of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, and their preparation and use as pharmaceuticals wherein U, R1, R2 and R3 are as defined herein.
PURINE DERIVATIVES FOR USE AS ADENOSIN A-2A RECEPTOR AGONISTS
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Page/Page column 46, (2010/11/08)
Compounds of formula (I) in free or salt form, wherein R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine A2A receptor,
Synthesis of optically active β,γ-alkynylglycine derivatives
Meffre, Patrick,Gauzy, Laurence,Branquet, Eric,Durand, Philippe,Le Goffic, Francois
, p. 11215 - 11238 (2007/10/03)
Full results on the first synthesis of optically active β,γ-alkynylglycine derivatives from naturally occurring L-serine are described. The methodology uses L-serinal as a key intermediate and allows great versatility in the introduction of N-protective groups and of alkyne substitution. The N-Boc protected β,γ-alkynylglycine derivatives described have ee greater than 90%.
En route to optically active ethynylglycine derivatives
Meffre, Patrick,Gauzy, Laurence,Perdigues, Chantal,Desanges-Levecque, Florence,Branquet, Eric,Durand, Philippe,Le Goffic, Francois
, p. 877 - 880 (2007/10/02)
First results in the synthesis of chiral non racemic ethynylglycine derivatives from protected L-serinal are described.
A New Method for the Synthesis of Amides from Amines: Ruthenium Tetroxide Oxidation of N-Protected Alkylamines
Tanaka, Ken-Ichi,Yoshifuji, Shigeyuki,Nitta, Yoshihiro
, p. 3125 - 3129 (2007/10/02)
A simple synthetic method for the preparation of amides from the corresponding primary alkylamines was elaborated using ruthenium tetroxide (RuO4) oxidation as a key step.
